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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-22
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pubmed:abstractText |
Liver X receptors (LXR) have been implicated in cholesterol homeostasis. Agonists of LXR are expected to increase cholesterol efflux, lower LDL, and raise HDL levels. Screening of a natural product library of plant extracts using a LXR-SPA binding assay and bioassay-guided fractionation of the bark and stem extract of Garcinia humilis led to the discovery of a new polyisoprenylated benzophenone named guttiferone I (1). The IC(50) value for this compound in the LXRalpha-SPA binding assay was 3.4 muM. Details of the isolation, structure elucidation, and ligand binding activity of 1 are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0163-3864
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pubmed:author |
pubmed-author:AliAishaA,
pubmed-author:BorrisRobert PRP,
pubmed-author:GuanZiqiangZ,
pubmed-author:HerathKithsiriK,
pubmed-author:JayasuriyaHiranthiH,
pubmed-author:MacnaulKarenK,
pubmed-author:MenkeJohn GJG,
pubmed-author:OndeykaJohn GJG,
pubmed-author:SchulmanMarvin JMJ,
pubmed-author:SharmaNeelamN,
pubmed-author:SinghSheo BSB,
pubmed-author:StevensonDennisD,
pubmed-author:StijfhoornEirikE,
pubmed-author:WangJianhuaJ
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
617-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.
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pubmed:affiliation |
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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