| pubmed-article:15843557 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15843557 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15843557 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15843557 | lifeskim:mentions | umls-concept:C0248868 | lld:lifeskim |
| pubmed-article:15843557 | lifeskim:mentions | umls-concept:C0241526 | lld:lifeskim |
| pubmed-article:15843557 | lifeskim:mentions | umls-concept:C0769224 | lld:lifeskim |
| pubmed-article:15843557 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15843557 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15843557 | pubmed:dateCreated | 2005-4-21 | lld:pubmed |
| pubmed-article:15843557 | pubmed:abstractText | Stimulation of the TCR leads to an oscillatory release of free calcium that activates members of the calcium/calmodulin-dependent protein kinase II (CaMKII) family. The CaMKII molecules have profound and lasting effects on cellular signaling in several cell types, yet the role of CaMKII in T cells is still poorly characterized. In this report we describe a splice variant of CaMKIIbeta, CaMKIIbeta'e, in mouse T cells. We have determined its function, along with that of CaMKIIgamma, by introducing the active and kinase-dead mutants into activated P14 TCR transgenic T cells using retroviral transduction. Active CaMKII enhanced the proliferation and cytotoxic activity of T cells while reducing their IL-2 production. Furthermore, it induced a profound state of unresponsiveness that could be overcome only by prolonged culture in IL-2. These results indicate that members of the CaMKII family play an important role in regulation of CD8 T cell proliferation, cytotoxic effector function, and the response to restimulation. | lld:pubmed |
| pubmed-article:15843557 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15843557 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15843557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15843557 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15843557 | pubmed:month | May | lld:pubmed |
| pubmed-article:15843557 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15843557 | pubmed:author | pubmed-author:GascoigneNich... | lld:pubmed |
| pubmed-article:15843557 | pubmed:author | pubmed-author:ZalTomaszT | lld:pubmed |
| pubmed-article:15843557 | pubmed:author | pubmed-author:HedrickStephe... | lld:pubmed |
| pubmed-article:15843557 | pubmed:author | pubmed-author:Ch'enIrene... | lld:pubmed |
| pubmed-article:15843557 | pubmed:author | pubmed-author:LinMeei YunMY | lld:pubmed |
| pubmed-article:15843557 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15843557 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15843557 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15843557 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15843557 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15843557 | pubmed:pagination | 5583-92 | lld:pubmed |
| pubmed-article:15843557 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15843557 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15843557 | pubmed:articleTitle | A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. | lld:pubmed |
| pubmed-article:15843557 | pubmed:affiliation | Division of Biological Sciences, The Cancer Center, and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. | lld:pubmed |
| pubmed-article:15843557 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15843557 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15843557 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15843557 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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