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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-4-21
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pubmed:abstractText |
Interleukin-10 is an anti-inflammatory and immunomodulatory cytokine. Interleukin-10 deficient mice are prone to develop chronic colitis. Administration of recombinant human interleukin-10 has been proposed to have a beneficial effect in a subgroup of patients with Crohn's disease. Recently, we found an interleukin-10 Gly15Arg mutation in a family with Crohn's disease which is associated with reduced interleukin-10 secretion by in vitro stimulated monocytes and lymphocytes. We hypothesised that this interleukin-10 mutation plays a role in maintaining the inflammatory process in Crohn's disease in some families.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1590-8658
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
330-5
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pubmed:dateRevised |
2008-5-13
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pubmed:meshHeading |
pubmed-meshheading:15843082-Adolescent,
pubmed-meshheading:15843082-Adult,
pubmed-meshheading:15843082-Aged,
pubmed-meshheading:15843082-Aged, 80 and over,
pubmed-meshheading:15843082-Arginine,
pubmed-meshheading:15843082-Crohn Disease,
pubmed-meshheading:15843082-DNA Mutational Analysis,
pubmed-meshheading:15843082-Female,
pubmed-meshheading:15843082-Genetic Predisposition to Disease,
pubmed-meshheading:15843082-Glycine,
pubmed-meshheading:15843082-Humans,
pubmed-meshheading:15843082-Interleukin-10,
pubmed-meshheading:15843082-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15843082-Male,
pubmed-meshheading:15843082-Middle Aged,
pubmed-meshheading:15843082-Netherlands,
pubmed-meshheading:15843082-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:15843082-Point Mutation,
pubmed-meshheading:15843082-Restriction Mapping
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pubmed:year |
2005
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pubmed:articleTitle |
A functional interleukin-10 mutation in Dutch patients with Crohn's disease.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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