15842590

Source:http://linkedlifedata.com/resource/pubmed/id/15842590

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012655, umls-concept:C0021390, umls-concept:C0031437, umls-concept:C0035820, umls-concept:C0678951, umls-concept:C1333196
pubmed:issue	5
pubmed:dateCreated	2005-4-21
pubmed:abstractText	Emerging data indicate that alterations in cytokine synthesis may play a role in inflammatory bowel disease (IBD) pathogenesis. The differential production of cytokines has been linked to single nucleotide polymorphisms in gene promoter regions, signal sequences, and gene introns. The aim of this study was to assess the relationship between polymorphisms involving five cytokine genes (TNF-alpha, TGF-beta, IL-10, IL-6, and IFN-gamma), and IBD susceptibility and disease phenotype.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0421030
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Codon, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6, http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Protein Sorting Signals, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0002-9270
pubmed:author	pubmed-author:BernsteinCharles NCN, pubmed-author:CantorMichael JMJ, pubmed-author:NickersonPeterP
pubmed:issnType	Print
pubmed:volume	100
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1134-42
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:15842590-Adult, pubmed-meshheading:15842590-Codon, pubmed-meshheading:15842590-Colitis, Ulcerative, pubmed-meshheading:15842590-Crohn Disease, pubmed-meshheading:15842590-Cytokines, pubmed-meshheading:15842590-Female, pubmed-meshheading:15842590-Genetic Predisposition to Disease, pubmed-meshheading:15842590-Humans, pubmed-meshheading:15842590-Inflammatory Bowel Diseases, pubmed-meshheading:15842590-Interferon-gamma, pubmed-meshheading:15842590-Interleukin-10, pubmed-meshheading:15842590-Interleukin-6, pubmed-meshheading:15842590-Introns, pubmed-meshheading:15842590-Lymphotoxin-alpha, pubmed-meshheading:15842590-Male, pubmed-meshheading:15842590-Phenotype, pubmed-meshheading:15842590-Point Mutation, pubmed-meshheading:15842590-Polymorphism, Genetic, pubmed-meshheading:15842590-Polymorphism, Single Nucleotide, pubmed-meshheading:15842590-Promoter Regions, Genetic, pubmed-meshheading:15842590-Protein Sorting Signals, pubmed-meshheading:15842590-Tumor Necrosis Factor-alpha
pubmed:year	2005
pubmed:articleTitle	The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease.
pubmed:affiliation	Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't