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rdf:type |
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lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0009325,
umls-concept:C0017667,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033268,
umls-concept:C0040690,
umls-concept:C0078058,
umls-concept:C1256770,
umls-concept:C1328818,
umls-concept:C1710082
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pubmed:issue |
7
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|
pubmed:dateCreated |
2005-6-21
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pubmed:abstractText |
The podocyte is bathed in an angiotensin II (AngII)-rich ultrafiltrate, but the impact of AngII on podocyte pathobiology is not well known. Because podocytes play a direct role in the glomerular basement membrane (GBM) thickening of diabetes, the alpha3(IV) collagen chain was examined. Podocyte expression of alpha3(IV) collagen may involve the transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) systems.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:month |
Jul
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pubmed:issn |
0931-0509
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
20
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1320-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15840669-Angiotensin II,
pubmed-meshheading:15840669-Animals,
pubmed-meshheading:15840669-Autoantigens,
pubmed-meshheading:15840669-Cell Culture Techniques,
pubmed-meshheading:15840669-Collagen Type IV,
pubmed-meshheading:15840669-Dose-Response Relationship, Drug,
pubmed-meshheading:15840669-Epithelial Cells,
pubmed-meshheading:15840669-Kidney Glomerulus,
pubmed-meshheading:15840669-Mice,
pubmed-meshheading:15840669-Signal Transduction,
pubmed-meshheading:15840669-Time Factors,
pubmed-meshheading:15840669-Transforming Growth Factor beta,
pubmed-meshheading:15840669-Vascular Endothelial Growth Factor A,
pubmed-meshheading:15840669-Vasoconstrictor Agents
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pubmed:year |
2005
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pubmed:articleTitle |
Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy.
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pubmed:affiliation |
Renal-Electrolyte and Hypertension Division of the University of Pennsylvania, Philadelphia, PA, USA. chens@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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