Source:http://linkedlifedata.com/resource/pubmed/id/15838534
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2005-8-25
|
| pubmed:abstractText |
Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders (ED) with complex genetic and environmental components. Genetic studies and animal models support the participation of brain-derived neurotrophic factor (BDNF) in the vulnerability to AN and BN. We investigated the genetic contribution of the BDNF-specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) to the susceptibility to ED. We have screened the entire NTRK2 gene in 91 patients with ED and have identified 14 single-nucleotide polymorphisms (SNPs). A population-based association study with six SNPs from the NTRK2 locus was performed in 164 ED patients and 121 controls. Significant evidence of association for markers -69C>G and IVS13+40G>A was detected. We also observed a strong association between the C-A-insC haplotype (-69/IVS13+40/2784-2785) and binge-eating/purging AN (ANP, P=0.006; OR=2.27), and a reduced frequency of haplotype G-A-delCl in BN patients (P=0.034; OR=0.6). The analysis of ED-related phenotypes revealed a clear association between NTRK2, high scores of Harm avoidance measured by the temperament and character inventory (TCI-R; P=0.003) and minimum body mass index (minBMI; P<0.001). Our data support a contribution of NTRK2 to the genetic susceptibility of ED, mainly ANP, and ED-related phenotypic traits, such as Harm avoidance and minBMI.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1359-4184
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
851-60
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:15838534-Adult,
pubmed-meshheading:15838534-Anorexia Nervosa,
pubmed-meshheading:15838534-Avoidance Learning,
pubmed-meshheading:15838534-Body Mass Index,
pubmed-meshheading:15838534-Bulimia,
pubmed-meshheading:15838534-Chromosome Mapping,
pubmed-meshheading:15838534-Exons,
pubmed-meshheading:15838534-Female,
pubmed-meshheading:15838534-Genetic Predisposition to Disease,
pubmed-meshheading:15838534-Humans,
pubmed-meshheading:15838534-Introns,
pubmed-meshheading:15838534-Male,
pubmed-meshheading:15838534-Polymerase Chain Reaction,
pubmed-meshheading:15838534-Polymorphism, Single Nucleotide,
pubmed-meshheading:15838534-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:15838534-Receptor, trkB,
pubmed-meshheading:15838534-Reference Values,
pubmed-meshheading:15838534-Risk-Taking
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index.
|
| pubmed:affiliation |
Genes and Disease Program, Center for Genomic Regulation, Barcelona, Catalonia, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|