rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0024305,
umls-concept:C0034897,
umls-concept:C0055598,
umls-concept:C0087111,
umls-concept:C0205195,
umls-concept:C0393022,
umls-concept:C0580822,
umls-concept:C1413947,
umls-concept:C1521725,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1550594
|
pubmed:issue |
4
|
pubmed:dateCreated |
2005-4-19
|
pubmed:abstractText |
This report is the first to describe the successful treatment of a 14-year-old boy with aggressive recurrent, CD20-positive, B-cell large cell non-Hodgkin's lymphoma. The patient responded to three 4-week courses of rituximab (MabThera) given every 6 months and six cycles of CHOP given every 3 weeks in addition to a modified BFM 86 protocol. Transient neutropenia and lymphopenia occurred but with no clinical significance. The boy has been disease-free for the last 48 months (after 64 months of follow-up); his organ functions are normal. Rituximab and CHOP in addition to chemotherapy may be an alternative treatment for aggressive recurrent, pediatric CD20-positive B-cell large cell non-Hodgkin's lymphoma if highly intensive chemotherapy and stem cell transplantation are not available.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
1077-4114
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
27
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
223-6
|
pubmed:dateRevised |
2011-10-6
|
pubmed:meshHeading |
pubmed-meshheading:15838396-Adolescent,
pubmed-meshheading:15838396-Antibodies, Monoclonal,
pubmed-meshheading:15838396-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:15838396-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15838396-Cyclophosphamide,
pubmed-meshheading:15838396-Disease-Free Survival,
pubmed-meshheading:15838396-Doxorubicin,
pubmed-meshheading:15838396-Humans,
pubmed-meshheading:15838396-Lymphoma, B-Cell,
pubmed-meshheading:15838396-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:15838396-Male,
pubmed-meshheading:15838396-Neoplasm Recurrence, Local,
pubmed-meshheading:15838396-Prednisone,
pubmed-meshheading:15838396-Treatment Outcome,
pubmed-meshheading:15838396-Vincristine
|
pubmed:year |
2005
|
pubmed:articleTitle |
Rituximab combined with CHOP for successful treatment of aggressive recurrent, pediatric B-cell large cell non-Hodgkin's lymphoma.
|
pubmed:affiliation |
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, 40002 Khon Kaen, Thailand. arujet@kku.ac.th
|
pubmed:publicationType |
Journal Article,
Case Reports
|