Source:http://linkedlifedata.com/resource/pubmed/id/15838368
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2005-4-19
|
| pubmed:abstractText |
Inhaled nitric oxide (iNO) therapy is an effective treatment of pulmonary hypertension following left ventricular assist device (LVAD) implantation. As iNO may also modulate circulating endothelin-1 (ET-1) and big endothelin following LVAD implantation, we investigated the effects of iNO on ET-1 and big endothelin plasma concentration gradients. In order to assist weaning from cardiopulmonary bypass, iNO was administered to 15 consecutive patients with secondary pulmonary hypertension following implantation of a LVAD. Central venous, pulmonary arterial and arterial ET-1 and big endothelin plasma levels were measured preoperatively, on cardiopulmonary bypass prior to iNO administration, 12, 24 and 48 hours postoperatively, and 72 hours after weaning from iNO. The ET-1 gradients between central venous and pulmonary arterial plasma levels decreased significantly with time, and there was a trend for lower arterial-pulmonary arterial plasma concentration gradients. Big endothelin plasma concentration gradients were not altered significantly. The decrease in ET-1 plasma concentration gradients during and after iNO administration may reflect a restoration of the physiologic balance between the different vascular beds. This provides further evidence that intermittent iNO therapy may modulate ET-1 after LVAD implantation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1533-4023
|
| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
44 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S89-91
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| pubmed:meshHeading |
pubmed-meshheading:15838368-Administration, Inhalation,
pubmed-meshheading:15838368-Antihypertensive Agents,
pubmed-meshheading:15838368-Blood Pressure,
pubmed-meshheading:15838368-Cardiac Output, Low,
pubmed-meshheading:15838368-Cardiopulmonary Bypass,
pubmed-meshheading:15838368-Central Venous Pressure,
pubmed-meshheading:15838368-Down-Regulation,
pubmed-meshheading:15838368-Endothelin-1,
pubmed-meshheading:15838368-Female,
pubmed-meshheading:15838368-Heart Failure,
pubmed-meshheading:15838368-Heart-Assist Devices,
pubmed-meshheading:15838368-Humans,
pubmed-meshheading:15838368-Hypertension, Pulmonary,
pubmed-meshheading:15838368-Intraoperative Care,
pubmed-meshheading:15838368-Male,
pubmed-meshheading:15838368-Middle Aged,
pubmed-meshheading:15838368-Nitric Oxide,
pubmed-meshheading:15838368-Time Factors,
pubmed-meshheading:15838368-Treatment Outcome,
pubmed-meshheading:15838368-Ventricular Dysfunction, Right
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Nitric oxide inhalation modulates endothelin-1 plasma concentration gradients following left ventricular assist device implantation.
|
| pubmed:affiliation |
Deutsches Herzzentrum Berlin, Germany.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
|