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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-4-19
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pubmed:abstractText |
Down-regulation of Bcl-2 by the antisense G3139, currently under clinical evaluations, could restore chemosensitivity in otherwise resistant malignant cells. To date, the mechanism of intracellular accumulation of G3139 following in vivo administration remains to be elucidated. This study aimed to assess whether detectable intracellular concentrations of G3139 are achievable in vivo and how these relate to Bcl-2 down-regulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ByrdJohnJ,
pubmed-author:CaligiuriMichael AMA,
pubmed-author:ChanKenneth KKK,
pubmed-author:DaiGuoweiG,
pubmed-author:GreverMichaelM,
pubmed-author:HoytDaleD,
pubmed-author:KlisovicMarkoM,
pubmed-author:LiuShujunS,
pubmed-author:MarcucciGuidoG,
pubmed-author:ShenTianshengT,
pubmed-author:WhitmanSusanS
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2998-3008
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15837754-Acute Disease,
pubmed-meshheading:15837754-Base Sequence,
pubmed-meshheading:15837754-Cell Line, Tumor,
pubmed-meshheading:15837754-Chromatography, High Pressure Liquid,
pubmed-meshheading:15837754-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15837754-Humans,
pubmed-meshheading:15837754-K562 Cells,
pubmed-meshheading:15837754-Leukemia, Myeloid,
pubmed-meshheading:15837754-Oligonucleotides, Antisense,
pubmed-meshheading:15837754-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:15837754-RNA, Messenger,
pubmed-meshheading:15837754-Reproducibility of Results,
pubmed-meshheading:15837754-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15837754-Thionucleotides,
pubmed-meshheading:15837754-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia.
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pubmed:affiliation |
Division of Pharmaceutics, College of Medicine and Public Health, Ohio State University, Columbus, Ohio 43210, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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