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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-19
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pubmed:abstractText |
Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting crossresistance to prednisolone, vincristine, asparaginase, and daunorubicin. We also identified a distinct phenotype of discordant resistance to asparaginase and vincristine and 139 genes whose expression was associated with this novel phenotype. The expression of these genes discriminated treatment outcome in two independent patient populations, identifying a subset of patients with a markedly inferior outcome (37% +/- 13% 5 year DFS).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-Mercaptopurine,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Asparaginase,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Daunorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/E2A-Pbx1 fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisolone,
http://linkedlifedata.com/resource/pubmed/chemical/TEL-AML1 fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Vincristine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1535-6108
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pubmed:author |
pubmed-author:CheokMeyling HMH,
pubmed-author:EvansWilliam EWE,
pubmed-author:HollemanAmyA,
pubmed-author:Janka-SchaubGritta EGE,
pubmed-author:LugthartSanneS,
pubmed-author:PietersRobR,
pubmed-author:PuiChing-HonCH,
pubmed-author:RellingMary VMV,
pubmed-author:XXX,
pubmed-author:YangWenjianW,
pubmed-author:den BoerMonique LML
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-86
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15837626-6-Mercaptopurine,
pubmed-meshheading:15837626-Age Factors,
pubmed-meshheading:15837626-Antineoplastic Agents,
pubmed-meshheading:15837626-Asparaginase,
pubmed-meshheading:15837626-Cell Survival,
pubmed-meshheading:15837626-Child,
pubmed-meshheading:15837626-Cluster Analysis,
pubmed-meshheading:15837626-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:15837626-Daunorubicin,
pubmed-meshheading:15837626-Disease-Free Survival,
pubmed-meshheading:15837626-Drug Resistance, Multiple,
pubmed-meshheading:15837626-Drug Resistance, Neoplasm,
pubmed-meshheading:15837626-Gene Expression Profiling,
pubmed-meshheading:15837626-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15837626-Homeodomain Proteins,
pubmed-meshheading:15837626-Humans,
pubmed-meshheading:15837626-Neoplasm Recurrence, Local,
pubmed-meshheading:15837626-Oncogene Proteins, Fusion,
pubmed-meshheading:15837626-Phenotype,
pubmed-meshheading:15837626-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:15837626-Predictive Value of Tests,
pubmed-meshheading:15837626-Prednisolone,
pubmed-meshheading:15837626-Principal Component Analysis,
pubmed-meshheading:15837626-Proportional Hazards Models,
pubmed-meshheading:15837626-Translocation, Genetic,
pubmed-meshheading:15837626-Treatment Outcome,
pubmed-meshheading:15837626-Tumor Cells, Cultured,
pubmed-meshheading:15837626-Vincristine
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pubmed:year |
2005
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pubmed:articleTitle |
Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.
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pubmed:affiliation |
Hematological Malignancy Program, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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