Source:http://linkedlifedata.com/resource/pubmed/id/15837216
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
24
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pubmed:dateCreated |
2005-4-19
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pubmed:abstractText |
Recent prophylactic vaccine trials inducing virus-specific CD8+ T-cell responses have shown control of primary infections of a pathogenic simian-human immunodeficiency virus (SHIV) in macaques. In the chronic phase, therapeutic immunization replenishing virus-specific CD8+ T-cells is likely to contribute to sustained control of virus replication. In this study, we have administered a recombinant Sendai virus (SeV) vector into five rhesus macaques that had received prophylactic vaccinations and had controlled SHIV replication for more than 1 year after challenge. Our results indicate that virus-specific CD8+ T-cell responses can be expanded and broadened by therapeutic immunization with SeV vectors in the chronic phase after prophylactic vaccine-based control of primary immunodeficiency virus infections.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:HasegawaMamoruM,
pubmed-author:HigashiharaEijiE,
pubmed-author:HorieShigeoS,
pubmed-author:IgarashiHirokoH,
pubmed-author:IidaAkihiroA,
pubmed-author:KanoMunehideM,
pubmed-author:KatoMoriakiM,
pubmed-author:MatanoTetsuroT,
pubmed-author:NagaiYoshiyukiY,
pubmed-author:NakamuraHiromiH,
pubmed-author:SasakiYuriY,
pubmed-author:SataTetsutaroT,
pubmed-author:TakedaAkikoA
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3166-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15837216-Animals,
pubmed-meshheading:15837216-DNA,
pubmed-meshheading:15837216-Gene Products, gag,
pubmed-meshheading:15837216-Immunization,
pubmed-meshheading:15837216-Lymphocyte Count,
pubmed-meshheading:15837216-Macaca mulatta,
pubmed-meshheading:15837216-Male,
pubmed-meshheading:15837216-Monocytes,
pubmed-meshheading:15837216-RNA, Viral,
pubmed-meshheading:15837216-Sendai virus,
pubmed-meshheading:15837216-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:15837216-T-Lymphocytes,
pubmed-meshheading:15837216-Viral Load
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pubmed:year |
2005
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pubmed:articleTitle |
Induction of Gag-specific T-cell responses by therapeutic immunization with a Gag-expressing Sendai virus vector in macaques chronically infected with simian-human immunodeficiency virus.
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pubmed:affiliation |
Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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