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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-4-19
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pubmed:abstractText |
Myelination of peripheral nerves by Schwann cells requires a large amount of lipid and cholesterol biosynthesis. To understand the transcriptional coordination of the myelination process, we have investigated the developmental relationship between early growth response 2 (Egr2)/Krox20--a pivotal regulator of peripheral nerve myelination--and the sterol regulatory element binding protein (SREBP) pathway, which controls expression of cholesterol/lipid biosynthetic genes. During myelination of sciatic nerve, there is a very significant induction of SREBP1 and SREBP2, as well as their target genes, suggesting that the SREBP transactivators are important regulators in the myelination process. Egr2/Krox20 does not appear to directly regulate the levels of SREBP pathway components, but rather, we found that Egr2/Krox20 and SREBP transactivators can synergistically activate promoters of several SREBP target genes, indicating that direct induction of cholesterol/lipid biosynthetic genes by Egr2/Krox20 is a part of the myelination program regulated by this transactivator.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EGR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Egr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/SREBF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SREBF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Srebf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Srebf2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Regulatory Element Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Regulatory Element Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-3042
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-48
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15836632-Animals,
pubmed-meshheading:15836632-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:15836632-Cell Line,
pubmed-meshheading:15836632-Cholesterol,
pubmed-meshheading:15836632-DNA-Binding Proteins,
pubmed-meshheading:15836632-Drug Synergism,
pubmed-meshheading:15836632-Early Growth Response Protein 2,
pubmed-meshheading:15836632-Humans,
pubmed-meshheading:15836632-Mice,
pubmed-meshheading:15836632-Mice, Inbred C57BL,
pubmed-meshheading:15836632-Mice, Inbred DBA,
pubmed-meshheading:15836632-Mice, Knockout,
pubmed-meshheading:15836632-Mice, Transgenic,
pubmed-meshheading:15836632-Myelin Sheath,
pubmed-meshheading:15836632-Nerve Fibers, Myelinated,
pubmed-meshheading:15836632-Peripheral Nerves,
pubmed-meshheading:15836632-Sciatic Nerve,
pubmed-meshheading:15836632-Sterol Regulatory Element Binding Protein 1,
pubmed-meshheading:15836632-Sterol Regulatory Element Binding Protein 2,
pubmed-meshheading:15836632-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination.
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pubmed:affiliation |
Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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