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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-4-19
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pubmed:abstractText |
Experiments performed with Holtzman rats demonstrated that brain iron (Fe) was lower by postnatal day 13 (P13) in pups born and nursed by dams that began copper-deficient (-Cu) treatment at embryonic day 7. Transcardial perfusion of P24-P26 males and females to remove blood Fe contamination revealed that brain Fe was still 20% lower in -Cu than +Cu rats. Estimated blood content of brain for -Cu rats was greater than for +Cu rats; for all groups, values ranged between 0.43 and 1.03%. Using group-specific data and regression analyses, r = 0.99, relating blood Fe to hemoglobin, brain Fe in non-perfused rats in a replicate study was lower by 33% at P13 and 39% at P24 in -Cu rats. Brain extracts from these rats and from P50 rats from a post-weaning model were compared by immunoblotting for transferrin receptor (TfR1). P24 brain -Cu/+Cu TfR1 was 3.08, suggesting that brains of -Cu rats were indeed Fe deficient. This ratio in P13 rats was 1.44, p < 0.05. No change in P50 -Cu rat brain TfR1 or Fe content was detected despite a 50% reduction in plasma Fe. The results suggest that brain Fe accumulation depends on adequate Cu nutriture during perinatal development.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-10079701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-1052031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-10926291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-1201239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-12151537,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-12621119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-12704220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-12730445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-13310589,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-15284387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-169321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-3998865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-4368537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-5763444,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15836628-9721738
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-3042
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
698-705
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15836628-Animals,
pubmed-meshheading:15836628-Animals, Newborn,
pubmed-meshheading:15836628-Animals, Suckling,
pubmed-meshheading:15836628-Brain,
pubmed-meshheading:15836628-Copper,
pubmed-meshheading:15836628-Female,
pubmed-meshheading:15836628-Iron,
pubmed-meshheading:15836628-Male,
pubmed-meshheading:15836628-Pregnancy,
pubmed-meshheading:15836628-Prenatal Exposure Delayed Effects,
pubmed-meshheading:15836628-Rats,
pubmed-meshheading:15836628-Rats, Sprague-Dawley,
pubmed-meshheading:15836628-Weaning
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pubmed:year |
2005
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pubmed:articleTitle |
Rat brain iron concentration is lower following perinatal copper deficiency.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, University of Minnesota, Duluth, Minnesota 55812, USA. jprohask@d.umn.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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