Linked Life Data

15835390

Source:http://linkedlifedata.com/resource/pubmed/id/15835390

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2005-4-19
pubmed:abstractText
Previously, we reported that the inhibition of Rho-kinase by a microinjection of Y-27632 or the transfection of dominant-negative Rho-kinase into cells of the nucleus tractus solitarii (NTS) reduces blood pressure, heart rate, and sympathetic nerve activity. In the present study, we examined the effects of another Rho-kinase inhibitor, hydroxyfasudil, on blood pressure and heart rate in anesthetized rats. The results were compared between normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). The microinjection of hydroxyfasudil was performed unilaterally or bilaterally into the NTS of WKY rats and SHR. A unilateral microinjection of hydroxyfasudil elicited depressor and bradycardic responses in SHR but not in WKY rats. A bilateral microinjection of hydroxyfasudil elicited depressor and bradycardic responses in both SHR and WKY rats. However, the magnitude of the decrease in these variables was greater in SHR than in WKY rats. The expression levels of RhoA in the membrane fraction and phosphorylated ERM family (ezrin, radixin, and moesin) in the NTS were greater in SHR than in WKY rats. These results suggest that the microinjection of hydroxyfasudil into the NTS causes cardiovascular responses similar to those caused by Y-27632 and that these responses are probably mediated by the inhibition of Rho-kinase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1064-1963
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
269-77
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15835390-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, pubmed-meshheading:15835390-Animals, pubmed-meshheading:15835390-Blood Pressure, pubmed-meshheading:15835390-Blotting, Western, pubmed-meshheading:15835390-Disease Models, Animal, pubmed-meshheading:15835390-Heart Rate, pubmed-meshheading:15835390-Hypertension, pubmed-meshheading:15835390-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15835390-Male, pubmed-meshheading:15835390-Microinjections, pubmed-meshheading:15835390-Protein-Serine-Threonine Kinases, pubmed-meshheading:15835390-Rats, pubmed-meshheading:15835390-Rats, Inbred SHR, pubmed-meshheading:15835390-Rats, Inbred WKY, pubmed-meshheading:15835390-Solitary Nucleus, pubmed-meshheading:15835390-rho-Associated Kinases, pubmed-meshheading:15835390-rhoA GTP-Binding Protein
pubmed:articleTitle
Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats.
pubmed:affiliation
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't