Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-6-18
|
| pubmed:abstractText |
We investigated the potential role of interleukin-6 as a mediator of the acute-phase reaction (APR) in patients with acute myocardial infarction. Of the six patients studied, five demonstrated increased plasma interleukin-6 levels. Interleukin-6 levels began to increase at 14 hours (mean; range = 8 to 20 hours) after the initial complaints and reached maximal levels of 28 to 250 U/mL (normal values less than 10 U/mL) after 36 hours (mean; range = 24 to 52 hours). No correlation was seen between the size of the interfaction as indicated by creatine kinase MB assays and the extent of the interleukin-6 increases (r = 0.44; p = 0.38). As an indicator of the APR, plasma C-reactive protein (CRP) levels were measured. CRP levels began to increase after 16 hours (mean; range = 8 to 24 hours) and reached maximum levels of 56 to 322 mg/L (normal values less than 3 mg/L) after 65 hours (mean; range = 48 to 92 hours). The increase of the interleukin-6 level preceded the increase of the CRP level in three patients and was simultaneous in two patients. Maximal interleukin-6 levels correlated significantly with maximal CRP levels (r = 0.96; p = 0.002). Thus these findings indicate that interleukin-6 is an important endogenous mediator for the APR in patients with acute myocardial infarction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-2143
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
119
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
574-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1583414-Acute Disease,
pubmed-meshheading:1583414-Acute-Phase Reaction,
pubmed-meshheading:1583414-C-Reactive Protein,
pubmed-meshheading:1583414-Creatine Kinase,
pubmed-meshheading:1583414-Humans,
pubmed-meshheading:1583414-Interleukin-6,
pubmed-meshheading:1583414-Myocardial Infarction,
pubmed-meshheading:1583414-Pilot Projects,
pubmed-meshheading:1583414-Time Factors
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Interleukin-6 release and the acute-phase reaction in patients with acute myocardial infarction: a pilot study.
|
| pubmed:affiliation |
Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|