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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-4-18
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pubmed:abstractText |
We investigated autoantibodies and their epitope(s) in Hashimoto's encephalopathy associated with Hashimoto's thyroiditis. In a proteomic analysis, they proved to recognize alpha-enolase. We further searched the epitope region in alpha-enolase using different regions of recombinant proteins expressed in cultured human cells. The amino terminal region was recognized by autobodies from a much higher proportion of patients with Hashimoto's encephalopathy (83.3%; 5/6) than from patients with Hashimoto's thyroiditis (11.8%; 2/17), and not at all by sera from controls (25 healthy individuals and 25 controls with other neurological disorders) (0%; 0/50). Neither the carboxyl terminal nor the mid-region of alpha-enolase showed specificity for Hashimoto's encephalopathy. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker for Hashimoto's encephalopathy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ENO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphopyruvate Hydratase,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:FujiiAA,
pubmed-author:HigaHH,
pubmed-author:ItoTT,
pubmed-author:KimuraAA,
pubmed-author:KuriyamaMM,
pubmed-author:SatomiSS,
pubmed-author:SuzukiHH,
pubmed-author:SuzukiMM,
pubmed-author:YamamuraOO,
pubmed-author:YamashitaMM,
pubmed-author:YonedaMM,
pubmed-author:YuasaTT
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pubmed:issnType |
Print
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
130-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15833368-Adult,
pubmed-meshheading:15833368-Aged,
pubmed-meshheading:15833368-Autoantibodies,
pubmed-meshheading:15833368-Biological Markers,
pubmed-meshheading:15833368-Blotting, Western,
pubmed-meshheading:15833368-Brain,
pubmed-meshheading:15833368-Cells, Cultured,
pubmed-meshheading:15833368-DNA-Binding Proteins,
pubmed-meshheading:15833368-Echocardiography,
pubmed-meshheading:15833368-Epitopes,
pubmed-meshheading:15833368-Female,
pubmed-meshheading:15833368-Humans,
pubmed-meshheading:15833368-Middle Aged,
pubmed-meshheading:15833368-Phosphopyruvate Hydratase,
pubmed-meshheading:15833368-Recombinant Proteins,
pubmed-meshheading:15833368-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:15833368-Thyroiditis, Autoimmune,
pubmed-meshheading:15833368-Tumor Markers, Biological,
pubmed-meshheading:15833368-Tumor Suppressor Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy.
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pubmed:affiliation |
Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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