Source:http://linkedlifedata.com/resource/pubmed/id/15831815
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2005-5-13
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| pubmed:abstractText |
To clarify the role of histamine-producing cells and its origin in atherosclerosis, we investigated histidine decarboxylase (HDC; histamine-producing enzyme) expression in murine arteries with vascular injuries after the animal had received transplanted bone marrow (BM) from green fluorescent protein (GFP)-transgenic mice. The neointima in the ligated carotid arteries contained BM-derived HDC+ cells that expressed macrophage (Mac-3) or smooth muscle cell antigen (alpha-SMA). In contrast, the HDC+ BM-derived cells, which were positive for Mac-3, were mainly located in the adventitia in the cuff replacement model. In apolipoprotein E-knockout mice on a high cholesterol diet, BM-derived cells expressing Mac-3 in the atheromatous plaques were also positive for HDC. In comparison with wild-type mice, HDC-/- mice showed reduced neointimal thickening and a decreased intima-to-media ratio after ligation and cuff replacement. These results indicate that histamine produced from BM-derived progenitor cells, which could transdifferentiate into SMC- or macrophage-like cells, are important for the formation of neointima and atheromatous plaques.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
1524-4571
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
13
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| pubmed:volume |
96
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
974-81
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15831815-Animals,
pubmed-meshheading:15831815-Apolipoproteins E,
pubmed-meshheading:15831815-Arteries,
pubmed-meshheading:15831815-Arteriosclerosis,
pubmed-meshheading:15831815-Bone Marrow Cells,
pubmed-meshheading:15831815-Carotid Arteries,
pubmed-meshheading:15831815-Green Fluorescent Proteins,
pubmed-meshheading:15831815-Histamine,
pubmed-meshheading:15831815-Histidine Decarboxylase,
pubmed-meshheading:15831815-Hyperlipidemias,
pubmed-meshheading:15831815-Ligation,
pubmed-meshheading:15831815-Macrophages,
pubmed-meshheading:15831815-Mice,
pubmed-meshheading:15831815-Mice, Inbred C57BL,
pubmed-meshheading:15831815-Mice, Knockout,
pubmed-meshheading:15831815-Mice, Transgenic,
pubmed-meshheading:15831815-Muscle, Smooth, Vascular,
pubmed-meshheading:15831815-Stem Cells,
pubmed-meshheading:15831815-Tunica Intima
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis.
|
| pubmed:affiliation |
Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental of Health, Kitakyushu, Japan. yasu-s@med.uoeh-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|