Linked Life Data

15831567

Source:http://linkedlifedata.com/resource/pubmed/id/15831567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-6-10
pubmed:abstractText
Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor. Kisspeptins and GPR54 have been implicated in the neuroendocrine regulation of GnRH secretion. To test the hypothesis that testosterone regulates Kiss1 gene expression, we compared the expression of KiSS-1 mRNA among groups of intact, castrated, and castrated/testosterone (T)-treated male mice. In the arcuate nucleus (Arc), castration resulted in a significant increase in KiSS-1 mRNA, which was completely reversed with T replacement, whereas in the anteroventral periventricular nucleus, the results were the opposite, i.e. castration decreased and T increased KiSS-1 mRNA expression. In the Arc, the effects of T on KiSS-1 mRNA were completely mimicked by estrogen but only partially mimicked by dihydrotestosterone, a nonaromatizable androgen, suggesting that both estrogen receptor (ER) and androgen receptor (AR) play a role in T-mediated regulation of KiSS-1. Studies of the effects of T on KiSS-1 expression in mice with either a deletion of the ERalpha or a hypomorphic allele to the AR revealed that the effects of T are mediated by both ERalpha and AR pathways, which was confirmed by the presence of either ERalpha or AR coexpression in most KiSS-1 neurons in the Arc. These observations suggest that KiSS-1 neurons in the Arc, whose transcriptional activity is inhibited by T, are targets for the negative feedback regulation of GnRH secretion, whereas KiSS-1 neurons in the anteroventral periventricular nucleus, whose activity is stimulated by T, may mediate other T-dependent processes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2976-84
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:15831567-Animals, pubmed-meshheading:15831567-Body Weight, pubmed-meshheading:15831567-Brain, pubmed-meshheading:15831567-Dihydrotestosterone, pubmed-meshheading:15831567-Estradiol, pubmed-meshheading:15831567-Estrogen Receptor alpha, pubmed-meshheading:15831567-Hormones, pubmed-meshheading:15831567-In Situ Hybridization, pubmed-meshheading:15831567-Kisspeptins, pubmed-meshheading:15831567-Male, pubmed-meshheading:15831567-Mice, pubmed-meshheading:15831567-Mice, Inbred C57BL, pubmed-meshheading:15831567-Mice, Knockout, pubmed-meshheading:15831567-Orchiectomy, pubmed-meshheading:15831567-Prosencephalon, pubmed-meshheading:15831567-Proteins, pubmed-meshheading:15831567-RNA, Messenger, pubmed-meshheading:15831567-Receptors, Androgen, pubmed-meshheading:15831567-Testosterone, pubmed-meshheading:15831567-Tissue Distribution
pubmed:year
2005
pubmed:articleTitle
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse.
pubmed:affiliation
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195-7290, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural