|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4 Pt 1
|
|
pubmed:dateCreated |
2005-4-15
|
|
pubmed:abstractText |
Renal cytochrome P450 (CYP)-derived eicosanoids, hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DHETs), have been shown to affect renal function and blood pressure (BP). We recently reported that high fat (HF) diet treatment in male rats increases BP and decreases production of these eicosanoids in the kidneys. However, at what level the downregulation of renal eicosanoid synthesis occurs and whether the HF diet has any effects on the regulation of renal eicosanoid synthesis in female rats are not known. The purpose of this study was to determine renal CYP-derived eicosanoid synthesis and its association with BP regulation in HF male and female rats.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0895-7061
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
530-7
|
|
pubmed:dateRevised |
2009-9-28
|
|
pubmed:meshHeading |
pubmed-meshheading:15831364-Alkane 1-Monooxygenase,
pubmed-meshheading:15831364-Androgens,
pubmed-meshheading:15831364-Animals,
pubmed-meshheading:15831364-Arachidonic Acid,
pubmed-meshheading:15831364-Blood Pressure,
pubmed-meshheading:15831364-Cytochrome P-450 Enzyme System,
pubmed-meshheading:15831364-Dietary Fats,
pubmed-meshheading:15831364-Dihydrotestosterone,
pubmed-meshheading:15831364-Diuresis,
pubmed-meshheading:15831364-Dose-Response Relationship, Drug,
pubmed-meshheading:15831364-Eicosanoids,
pubmed-meshheading:15831364-Female,
pubmed-meshheading:15831364-Kidney,
pubmed-meshheading:15831364-Male,
pubmed-meshheading:15831364-Natriuresis,
pubmed-meshheading:15831364-Rats,
pubmed-meshheading:15831364-Rats, Sprague-Dawley,
pubmed-meshheading:15831364-Sex Factors,
pubmed-meshheading:15831364-Sodium
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Gender differences of renal CYP-derived eicosanoid synthesis in rats fed a high-fat diet.
|
|
pubmed:affiliation |
Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
