Linked Life Data

15830351

Source:http://linkedlifedata.com/resource/pubmed/id/15830351

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-6-21
pubmed:abstractText
P450-aromatase is the terminal estrogen-synthesizing enzyme and a key gene in avian sex determination. Aromatase is expressed specifically in female gonads, but not male gonads, at the onset of sexual differentiation. This enzyme shows temporal and spatial colocalization with the forkhead transcription factor FOXL2 in the embryonic chicken ovary, suggesting a causal link. Mutations in FOXL2 are associated with premature ovarian failure in humans. Foxl2 null mice also present with premature ovarian failure. Here, we show that FOXL2 expression is reduced but not abolished in chicken embryos subjected to experimental female to male sex-reversal with an aromatase inhibitor. This finding suggests that FOXL2 lies upstream of aromatase in avian sex determination, but that it responds to depleted estrogen synthesis. The reduction in FOXL2 expression may be accounted for by interruption of a positive feedback loop by means of estrogen, or the influence of testis promoting factors such as SOX9 and DMRT1 in the masculinized gonads.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1058-8388
pubmed:author
pubmed:issnType
Print
pubmed:volume
233
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1052-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary.
pubmed:affiliation
Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, VIC, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't