| pubmed-article:15829968 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15829968 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:15829968 | lifeskim:mentions | umls-concept:C0949486 | lld:lifeskim |
| pubmed-article:15829968 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:15829968 | lifeskim:mentions | umls-concept:C1333931 | lld:lifeskim |
| pubmed-article:15829968 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:15829968 | pubmed:issue | 7035 | lld:pubmed |
| pubmed-article:15829968 | pubmed:dateCreated | 2005-4-14 | lld:pubmed |
| pubmed-article:15829968 | pubmed:abstractText | Defining the molecular strategies that integrate diverse signalling pathways in the expression of specific gene programmes that are critical in homeostasis and disease remains a central issue in biology. This is particularly pertinent in cancer biology because downregulation of tumour metastasis suppressor genes is a common occurrence, and the underlying molecular mechanisms are not well established. Here we report that the downregulation of a metastasis suppressor gene, KAI1, in prostate cancer cells involves the inhibitory actions of beta-catenin, along with a reptin chromatin remodelling complex. This inhibitory function of beta-catenin-reptin requires both increased beta-catenin expression and recruitment of histone deacetylase activity. The coordinated actions of beta-catenin-reptin components that mediate the repressive state serve to antagonize a Tip60 coactivator complex that is required for activation; the balance of these opposing complexes controls the expression of KAI1 and metastatic potential. The molecular mechanisms underlying the antagonistic regulation of beta-catenin-reptin and the Tip60 coactivator complexes for the metastasis suppressor gene, KAI1, are likely to be prototypic of a selective downregulation strategy for many genes, including a subset of NF-kappaB target genes. | lld:pubmed |
| pubmed-article:15829968 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15829968 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15829968 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15829968 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15829968 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:NoseNN | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:SawyersCharle... | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:RoseDavid WDW | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:HuberOtmarO | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:RosenfeldMich... | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:ChungChin... | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:BaekSung... | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:KimJung HwaJH | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:OhgiKenneth... | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:TranChrisC | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:KimBogyouB | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:ChoiHee... | lld:pubmed |
| pubmed-article:15829968 | pubmed:author | pubmed-author:ChenCharlieC | lld:pubmed |
| pubmed-article:15829968 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15829968 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:15829968 | pubmed:volume | 434 | lld:pubmed |
| pubmed-article:15829968 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15829968 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15829968 | pubmed:pagination | 921-6 | lld:pubmed |
| pubmed-article:15829968 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15829968 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15829968 | pubmed:articleTitle | Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. | lld:pubmed |
| pubmed-article:15829968 | pubmed:affiliation | Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, South Korea. | lld:pubmed |
| pubmed-article:15829968 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15829968 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15829968 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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