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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7035
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pubmed:dateCreated |
2005-4-14
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pubmed:abstractText |
Defining the molecular strategies that integrate diverse signalling pathways in the expression of specific gene programmes that are critical in homeostasis and disease remains a central issue in biology. This is particularly pertinent in cancer biology because downregulation of tumour metastasis suppressor genes is a common occurrence, and the underlying molecular mechanisms are not well established. Here we report that the downregulation of a metastasis suppressor gene, KAI1, in prostate cancer cells involves the inhibitory actions of beta-catenin, along with a reptin chromatin remodelling complex. This inhibitory function of beta-catenin-reptin requires both increased beta-catenin expression and recruitment of histone deacetylase activity. The coordinated actions of beta-catenin-reptin components that mediate the repressive state serve to antagonize a Tip60 coactivator complex that is required for activation; the balance of these opposing complexes controls the expression of KAI1 and metastatic potential. The molecular mechanisms underlying the antagonistic regulation of beta-catenin-reptin and the Tip60 coactivator complexes for the metastasis suppressor gene, KAI1, are likely to be prototypic of a selective downregulation strategy for many genes, including a subset of NF-kappaB target genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD82,
http://linkedlifedata.com/resource/pubmed/chemical/CD82 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cd82 antigen, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/KAT5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/matrigel
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1476-4687
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pubmed:author |
pubmed-author:BaekSung HeeSH,
pubmed-author:ChenCharlieC,
pubmed-author:ChoiHee JuneHJ,
pubmed-author:ChungChin HaCH,
pubmed-author:HuberOtmarO,
pubmed-author:KimBogyouB,
pubmed-author:KimJung HwaJH,
pubmed-author:NoseNN,
pubmed-author:OhgiKenneth AKA,
pubmed-author:RoseDavid WDW,
pubmed-author:RosenfeldMichael GMG,
pubmed-author:SawyersCharles LCL,
pubmed-author:TranChrisC
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
434
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
921-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15829968-Acetyltransferases,
pubmed-meshheading:15829968-Animals,
pubmed-meshheading:15829968-Antigens, CD,
pubmed-meshheading:15829968-Antigens, CD82,
pubmed-meshheading:15829968-Cell Line, Tumor,
pubmed-meshheading:15829968-Chromatin Assembly and Disassembly,
pubmed-meshheading:15829968-Collagen,
pubmed-meshheading:15829968-Cytoskeletal Proteins,
pubmed-meshheading:15829968-Down-Regulation,
pubmed-meshheading:15829968-Drug Combinations,
pubmed-meshheading:15829968-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15829968-Histone Acetyltransferases,
pubmed-meshheading:15829968-Humans,
pubmed-meshheading:15829968-Laminin,
pubmed-meshheading:15829968-Male,
pubmed-meshheading:15829968-Membrane Glycoproteins,
pubmed-meshheading:15829968-Mice,
pubmed-meshheading:15829968-NF-kappa B,
pubmed-meshheading:15829968-Neoplasm Metastasis,
pubmed-meshheading:15829968-Neoplasm Transplantation,
pubmed-meshheading:15829968-Promoter Regions, Genetic,
pubmed-meshheading:15829968-Prostatic Neoplasms,
pubmed-meshheading:15829968-Proteoglycans,
pubmed-meshheading:15829968-Proto-Oncogene Proteins,
pubmed-meshheading:15829968-RNA, Messenger,
pubmed-meshheading:15829968-Trans-Activators,
pubmed-meshheading:15829968-Transcription, Genetic,
pubmed-meshheading:15829968-beta Catenin
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pubmed:year |
2005
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pubmed:articleTitle |
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
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pubmed:affiliation |
Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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