Linked Life Data

15829642

Source:http://linkedlifedata.com/resource/pubmed/id/15829642

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2005-4-14
pubmed:abstractText
Neural circuitry of the spinal superficial dorsal horn (SDH) (laminae I and II) and its relationship to pain and other somatosensory phenomena remain poorly understood. To gain information on this issue, synaptic connections between identified SDH neurons were studied in rat spinal cord slices by simultaneous whole-cell recordings from pairs of cells. Both excitatory and inhibitory connections were noted. This report focuses on the observed excitatory linkages. Synaptic excitatory connections between SDH neurons proved highly selective and consistently were unidirectional. Two patterns repeatedly appeared (for neuron classification, see Materials and Methods) (Grudt and Perl, 2002). Lamina II central neurons, with dorsal root (DR) C-fiber input, monosynaptically excited lamina II vertical neurons with DR Adelta input. Lamina II outer vertical neurons with DR Adelta input monosynaptically excited lamina I neurons. Some of the postsynaptic lamina I cells were shown to project rostrally. In contrast to the usual case for connected neurons, in unconnected pairs, primary afferent input to the same type of neuron proved closely similar. Together, these observations indicate that the neural circuitry in the SDH, including its substantia gelatinosa (lamina II), has an explicit organization in which particular combinations of neurons comprise modules arranged to modify and transmit sensory information arriving from Adelta and C primary afferent fibers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3900-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:15829642-6-Cyano-7-nitroquinoxaline-2,3-dione, pubmed-meshheading:15829642-Action Potentials, pubmed-meshheading:15829642-Animals, pubmed-meshheading:15829642-Electric Stimulation, pubmed-meshheading:15829642-Excitatory Amino Acid Antagonists, pubmed-meshheading:15829642-Excitatory Postsynaptic Potentials, pubmed-meshheading:15829642-Lysine, pubmed-meshheading:15829642-Models, Neurological, pubmed-meshheading:15829642-Nerve Net, pubmed-meshheading:15829642-Neurons, pubmed-meshheading:15829642-Rats, pubmed-meshheading:15829642-Rats, Sprague-Dawley, pubmed-meshheading:15829642-Reaction Time, pubmed-meshheading:15829642-Stilbamidines, pubmed-meshheading:15829642-Substance P, pubmed-meshheading:15829642-Substantia Gelatinosa, pubmed-meshheading:15829642-Synaptic Transmission, pubmed-meshheading:15829642-Tetrodotoxin
pubmed:year
2005
pubmed:articleTitle
Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II).
pubmed:affiliation
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural