Source:http://linkedlifedata.com/resource/pubmed/id/15829322
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2005-4-14
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pubmed:abstractText |
YKL-40 is a 40 kDa protein with possible involvement in tissue remodeling, cell proliferation and angiogenesis. Elevated serum YKL-40 levels in patients with metastatic cancers (including small cell lung cancer (SCLC)) are associated with poor prognosis. The aim of this study was to identify the cellular source of YKL-40 in SCLC patient biopsies and in a panel of 20 human SCLC lines cultured in vitro and in vivo in nude mice. In general, the SCLC cell lines had no or very limited (human) YKL-40 expression, whereas, by RT-PCR a pronounced murine (i.e., stromal) YKL-40 expression was present in all tumors. YKL-40 mRNA transcripts were detected by in situ hybridization in 9 of 10 biopsies from SCLC patients, and in each case the signal was localized in the peritumoral stroma in cells of typical macrophage morphology (confirmed by a CD68 macrophage specific stain). No YKL-40 mRNA expression was found in the cancer cells, in macrophages infiltrating the solid tumor areas, or in non-malignant tissue. In conclusion, the predominant source of elevated serum YKL-40 in SCLC is peritumoral macrophages.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adipokines,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/CHI3L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0169-5002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-31
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15829322-Adipokines,
pubmed-meshheading:15829322-Animals,
pubmed-meshheading:15829322-Autoantigens,
pubmed-meshheading:15829322-Carcinoma, Small Cell,
pubmed-meshheading:15829322-Cell Proliferation,
pubmed-meshheading:15829322-Gene Expression Profiling,
pubmed-meshheading:15829322-Glycoproteins,
pubmed-meshheading:15829322-Humans,
pubmed-meshheading:15829322-Lectins,
pubmed-meshheading:15829322-Lung Neoplasms,
pubmed-meshheading:15829322-Macrophages,
pubmed-meshheading:15829322-Mice,
pubmed-meshheading:15829322-Mice, Nude,
pubmed-meshheading:15829322-Neoplasm Invasiveness,
pubmed-meshheading:15829322-Neoplasms, Experimental,
pubmed-meshheading:15829322-Tumor Cells, Cultured
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pubmed:year |
2005
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pubmed:articleTitle |
Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer.
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pubmed:affiliation |
Laboratory of Experimental Oncology, Department of Molecular Pathology, University of Copenhagen, 11 Frederik V Vej, DK-2100 Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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