Source:http://linkedlifedata.com/resource/pubmed/id/15827015
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2005-4-13
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| pubmed:abstractText |
The potassium channel blocker 4-aminopyridine (4-AP) restored vertical smooth pursuit and gaze holding in light in one patient with upbeat (UBN) and in one with downbeat nystagmus (DBN). Without a visible target, however, 4-AP had no effect on UBN, but DBN vanished. We hypothesize that this difference in the effects of 4-AP, which is known to increase the excitability of cerebellar Purkinje cells, can be attributed to the different lesion sites involved in UBN and DBN.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0077-8923
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1039
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
528-31
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| pubmed:meshHeading |
pubmed-meshheading:15827015-4-Aminopyridine,
pubmed-meshheading:15827015-Adult,
pubmed-meshheading:15827015-Aged,
pubmed-meshheading:15827015-Eye Movements,
pubmed-meshheading:15827015-Humans,
pubmed-meshheading:15827015-Male,
pubmed-meshheading:15827015-Mesencephalon,
pubmed-meshheading:15827015-Nystagmus, Physiologic,
pubmed-meshheading:15827015-Potassium Channel Blockers,
pubmed-meshheading:15827015-Vision Disorders
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| pubmed:year |
2005
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| pubmed:articleTitle |
Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the mechanism of downbeat nystagmus.
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| pubmed:affiliation |
Center for Sensorimotor Research, Department of Neurology, Ludwig-Maximilian-University, Munich, Germany. sglasauer@nefo.med.uni-muenchen.de
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| pubmed:publicationType |
Journal Article,
Case Reports
|