Linked Life Data

15826936

Source:http://linkedlifedata.com/resource/pubmed/id/15826936

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15826936rdf:typepubmed:Citationlld:pubmed
pubmed-article:15826936lifeskim:mentionsumls-concept:C0021368lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C0026336lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C0021760lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C0024432lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C0004153lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C1456820lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C1996904lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C0449416lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C1880497lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C0024779lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C0205179lld:lifeskim
pubmed-article:15826936lifeskim:mentionsumls-concept:C2346714lld:lifeskim
pubmed-article:15826936pubmed:issue23lld:pubmed
pubmed-article:15826936pubmed:dateCreated2005-6-6lld:pubmed
pubmed-article:15826936pubmed:abstractTextTwo key features of atherosclerotic plaques that precipitate acute atherothrombotic vascular occlusion ("vulnerable plaques") are abundant inflammatory mediators and macrophages with excess unesterified, or "free," cholesterol (FC). Herein we show that FC accumulation in macrophages leads to the induction and secretion of two inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). The increases in TNF-alpha and IL-6 mRNA and protein were mediated by FC-induced activation of the IkappaB kinase/NF-kappaB pathway as well as activation of MKK3/p38, Erk1/2, and JNK1/2 mitogen-activated protein kinases (MAPK). Activation of IkappaB kinase and JNK1/2 was needed for the induction of both cytokines. However, MKK3/p38 signaling was specifically involved in TNF-alpha induction, and Erk1/2 signaling was required for IL-6. Most interestingly, activation of all of the signaling pathways and induction of both cytokines required cholesterol trafficking to the endoplasmic reticulum (ER). The CHOP branch of the unfolded protein response, an ER stress pathway, was required for Erk1/2 activation and IL-6 induction. In contrast, one or more other ER-related pathways were responsible for activation of p38, JNK1/2, and IkappaB kinase/NF-kappaB and for the induction of TNF-alpha. These data suggest a novel scenario in which cytokines are induced in macrophages by endogenous cellular events triggered by excess ER cholesterol rather than by exogenous immune cell mediators. Moreover, this model may help explain the relationship between FC accumulation and inflammation in vulnerable plaques.lld:pubmed
pubmed-article:15826936pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:languageenglld:pubmed
pubmed-article:15826936pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:citationSubsetIMlld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15826936pubmed:statusMEDLINElld:pubmed
pubmed-article:15826936pubmed:monthJunlld:pubmed
pubmed-article:15826936pubmed:issn0021-9258lld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:DavisRoger...lld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:LiYankunYlld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:TallAlan RARlld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:FlavellRichar...lld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:BrennerDavid...lld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:TabasIraIlld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:SchwabeRobert...lld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:Gerbod-Gianno...lld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:YaoPin MeiPMlld:pubmed
pubmed-article:15826936pubmed:authorpubmed-author:DeVries-Seimo...lld:pubmed
pubmed-article:15826936pubmed:issnTypePrintlld:pubmed
pubmed-article:15826936pubmed:day10lld:pubmed
pubmed-article:15826936pubmed:volume280lld:pubmed
pubmed-article:15826936pubmed:ownerNLMlld:pubmed
pubmed-article:15826936pubmed:authorsCompleteYlld:pubmed
pubmed-article:15826936pubmed:pagination21763-72lld:pubmed
pubmed-article:15826936pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:meshHeadingpubmed-meshheading:15826936...lld:pubmed
pubmed-article:15826936pubmed:year2005lld:pubmed
pubmed-article:15826936pubmed:articleTitleFree cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.lld:pubmed
pubmed-article:15826936pubmed:affiliationDepartment of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.lld:pubmed
pubmed-article:15826936pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15826936pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:15826936pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:15826936pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
entrez-gene:16193entrezgene:pubmedpubmed-article:15826936lld:entrezgene
entrez-gene:21926entrezgene:pubmedpubmed-article:15826936lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15826936lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:15826936lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15826936lld:pubmed
More...