rdf:type |
|
lifeskim:mentions |
umls-concept:C0003232,
umls-concept:C0020835,
umls-concept:C0020852,
umls-concept:C0030705,
umls-concept:C0043406,
umls-concept:C0546816,
umls-concept:C0871261,
umls-concept:C0949691,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
2
|
pubmed:dateCreated |
1992-6-12
|
pubmed:abstractText |
The IgA and IgG antibody response to plasmid-encoded outer membrane proteins was studied in 59 patients with yersinia-associated spondylarthropathy during 15 months of follow-up. Initially, all patients had specific IgA and IgG antibodies to the 36 and 46 kDa and 30% also to the 26 and 58 kDa released proteins, which correlated with the finding of virulent Yersinia bacilli in intestinal biopsies. IgA disappeared in 69% of untreated patients after nine months and persisted in 31% after one year. IgA disappeared within three to six months in 81% of the patients treated with antibiotics for four to six weeks and persisted in 6% after one year (p less than 0.002). IgG antibodies to the 36 and 46 kDa outer membrane proteins persisted in 80% of all patients. Disappearance of IgA was coupled with disappearance of yersinia from intestinal biopsies.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0300-8126
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
53-7
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:1582684-Adult,
pubmed-meshheading:1582684-Anti-Bacterial Agents,
pubmed-meshheading:1582684-Arthritis, Reactive,
pubmed-meshheading:1582684-Ciprofloxacin,
pubmed-meshheading:1582684-Doxycycline,
pubmed-meshheading:1582684-Female,
pubmed-meshheading:1582684-Humans,
pubmed-meshheading:1582684-Immunoglobulin A,
pubmed-meshheading:1582684-Immunoglobulin G,
pubmed-meshheading:1582684-Intestines,
pubmed-meshheading:1582684-Male,
pubmed-meshheading:1582684-Middle Aged,
pubmed-meshheading:1582684-Spondylitis,
pubmed-meshheading:1582684-Time Factors,
pubmed-meshheading:1582684-Trimethoprim,
pubmed-meshheading:1582684-Yersinia Infections,
pubmed-meshheading:1582684-Yersinia enterocolitica
|
pubmed:articleTitle |
Influence of antibiotics on IgA and IgG response and persistence of Yersinia enterocolitica in patients with Yersinia-associated spondylarthropathy.
|
pubmed:affiliation |
Laboratory for Public Health, Leeuwarden, The Netherlands.
|
pubmed:publicationType |
Journal Article
|