Linked Life Data

1582487

Source:http://linkedlifedata.com/resource/pubmed/id/1582487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-6-12
pubmed:abstractText
Various stages of Schistosoma mansoni were treated with a cytotoxin from Pseudomonas aeruginosa and their response to the damaging effect was studied in detail. Marker release and membrane potential measurements showed that the cytotoxin formed stable pores in all developmental stages. However, in juvenile 27-day-old worms, which are refractory to the killing effect of the cytotoxin, the pores had a smaller functional diameter as compared to other stages including 31-day-old worms. Furthermore, these resistant 27-day-old worms, but not susceptible older juvenile worms were able to repair the membrane lesions as shown by restoration of the resting membrane potential. In contrast, older juvenile and adult parasites were unable to cope with the breakdown of the resting potential induced by the cytotoxin. The results demonstrate the existence in 27-day-old schistosomes of effective repair mechanisms dealing with damage to the surface membrane.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-4894
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
340-7
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Schistosoma mansoni: stage-dependent formation and repair of membrane pores induced by a cytotoxin from Pseudomonas aeruginosa.
pubmed:affiliation
Institut für Tropenhygiene, Universität Heidelberg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't