|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2005-4-11
|
|
pubmed:abstractText |
Cardiac scintigraphic studies using (123)I-labeled metaiodobenzylguanidine ([(123)I]MIBG) have demonstrated heterogeneous myocardial accumulation of MIBG in diabetes. The accumulation has been found to correlate with a heterogeneous decrease in the expression of norepinephrine transporter (NET). In diabetic peripheral nerve tissue, polyol pathways are activated and cause nerve dysfunction and degeneration. However, there has been little research on the polyol pathway and cardiac sympathetic nerves. Therefore, to assess the influence of the polyol pathway on cardiac sympathetic nervous function, we investigated the regional accumulation of MIBG and NET protein expression in diabetic model rats treated with aldose reductase inhibitor (ARI) for the blockade of polyol pathways.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-Iodobenzylguanidine,
http://linkedlifedata.com/resource/pubmed/chemical/Aldehyde Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/ONO 2235,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/Rhodanine,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Sorbitol,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidines,
http://linkedlifedata.com/resource/pubmed/chemical/polyol
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1619-7070
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
32
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
438-42
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15821963-3-Iodobenzylguanidine,
pubmed-meshheading:15821963-Aldehyde Reductase,
pubmed-meshheading:15821963-Animals,
pubmed-meshheading:15821963-Diabetes Mellitus, Experimental,
pubmed-meshheading:15821963-Heart,
pubmed-meshheading:15821963-Male,
pubmed-meshheading:15821963-Metabolic Clearance Rate,
pubmed-meshheading:15821963-Myocardium,
pubmed-meshheading:15821963-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:15821963-Polymers,
pubmed-meshheading:15821963-Rats,
pubmed-meshheading:15821963-Rats, Sprague-Dawley,
pubmed-meshheading:15821963-Rhodanine,
pubmed-meshheading:15821963-Signal Transduction,
pubmed-meshheading:15821963-Sorbitol,
pubmed-meshheading:15821963-Streptozocin,
pubmed-meshheading:15821963-Sympathetic Nervous System,
pubmed-meshheading:15821963-Symporters,
pubmed-meshheading:15821963-Thiazolidines
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.
|
|
pubmed:affiliation |
Radioisotopes Research Laboratory, Hospital, Faculty of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
