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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-4
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pubmed:abstractText |
The PAS (PER-ARNT-SIM) helix-loop-helix transcription factor BMAL1 (also known as MOP3) is an essential component of the circadian pacemaker in mammals. Here we show that the retinoic acid receptor-related orphan receptor RORalpha (NR1F1) directly activates transcription of Bmal1 through two conserved RORalpha response elements that are required for cell-autonomous transcriptional oscillation of Bmal1 mRNA. Positive involvement of RORalpha in generation of the Bmal1 circadian oscillation was verified by behavioral analyses of RORalpha-deficient staggerer mice that showed aberrant locomotor activity and unstable rhythmicity. In cultured cells, loss of endogenous RORalpha protein resulted in a dampened circadian rhythm of Bmal1 transcription, further indicating that RORalpha is a functional component of the cell-autonomous core circadian clock. These results indicate that RORalpha acts to promote Bmal1 transcription, thereby maintaining a robust circadian rhythm.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ARNTL Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Arntl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Rora protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1545-9993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
441-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15821743-ARNTL Transcription Factors,
pubmed-meshheading:15821743-Animals,
pubmed-meshheading:15821743-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:15821743-Behavior, Animal,
pubmed-meshheading:15821743-Cell Line,
pubmed-meshheading:15821743-Circadian Rhythm,
pubmed-meshheading:15821743-DNA,
pubmed-meshheading:15821743-Gene Expression Regulation,
pubmed-meshheading:15821743-Mice,
pubmed-meshheading:15821743-Mutation,
pubmed-meshheading:15821743-Nuclear Receptor Subfamily 1, Group F, Member 1,
pubmed-meshheading:15821743-Promoter Regions, Genetic,
pubmed-meshheading:15821743-RNA, Messenger,
pubmed-meshheading:15821743-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:15821743-Response Elements,
pubmed-meshheading:15821743-Trans-Activators,
pubmed-meshheading:15821743-Transcription, Genetic,
pubmed-meshheading:15821743-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1.
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pubmed:affiliation |
Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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