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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5719
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pubmed:dateCreated |
2005-4-11
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pubmed:abstractText |
The molecular basis of gammadelta T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural gammadelta T cell population specific for the major histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates strongly with a somatically recombined TCRdelta complementarity-determining region 3 (CDR3) motif derived from germ line-encoded residues. Sequence diversity around these residues modulates TCR ligand-binding affinities, whereas V gene usage correlates mainly with tissue origin. These results show how an antigen-specific gammadelta TCR repertoire can be generated at a high frequency and suggest that gammadelta T cells recognize a limited number of antigens.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
8
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pubmed:volume |
308
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
252-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15821090-Amino Acid Sequence,
pubmed-meshheading:15821090-Antigens,
pubmed-meshheading:15821090-Binding Sites,
pubmed-meshheading:15821090-Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,
pubmed-meshheading:15821090-Histocompatibility Antigens Class I,
pubmed-meshheading:15821090-Humans,
pubmed-meshheading:15821090-Jurkat Cells,
pubmed-meshheading:15821090-Ligands,
pubmed-meshheading:15821090-Protein Conformation,
pubmed-meshheading:15821090-Proteins,
pubmed-meshheading:15821090-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:15821090-T-Lymphocytes
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pubmed:year |
2005
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pubmed:articleTitle |
Antigen recognition determinants of gammadelta T cell receptors.
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pubmed:affiliation |
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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