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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-11
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pubmed:abstractText |
Imatinib induces complete cytogenetic responses (CCR) in the majority of patients with chronic myeloid leukemia (CML) in chronic phase (CP). However, a subgroup of patients is refractory at the cytogenetic level. Clinically, it would be advantageous to identify such patients a priori, since they may benefit from more aggressive therapy.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:CrossmanLucy CLC,
pubmed-author:DeiningerMichael W NMW,
pubmed-author:DrukerBrian JBJ,
pubmed-author:HarringtonChristina ACA,
pubmed-author:HehlmannRüdigerR,
pubmed-author:HochhausAndreasA,
pubmed-author:HsiehYi-ChingYC,
pubmed-author:KrohnKnutK,
pubmed-author:LangeThoralfT,
pubmed-author:MoriMotomiM,
pubmed-author:NiederwieserDietger WDW,
pubmed-author:PaschkaPeterP
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pubmed:issnType |
Electronic
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-64
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15820940-Adult,
pubmed-meshheading:15820940-Aged,
pubmed-meshheading:15820940-Antineoplastic Agents,
pubmed-meshheading:15820940-Female,
pubmed-meshheading:15820940-Gene Expression Profiling,
pubmed-meshheading:15820940-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15820940-Humans,
pubmed-meshheading:15820940-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:15820940-Leukocytes,
pubmed-meshheading:15820940-Male,
pubmed-meshheading:15820940-Microarray Analysis,
pubmed-meshheading:15820940-Middle Aged,
pubmed-meshheading:15820940-Piperazines,
pubmed-meshheading:15820940-Protein Kinase Inhibitors,
pubmed-meshheading:15820940-Pyrimidines,
pubmed-meshheading:15820940-RNA, Neoplasm,
pubmed-meshheading:15820940-RNA, Ribosomal
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pubmed:year |
2005
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pubmed:articleTitle |
In chronic myeloid leukemia white cells from cytogenetic responders and non-responders to imatinib have very similar gene expression signatures.
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pubmed:affiliation |
Oregon Health & Science University Cancer Institute, Portland, OR 97239, USA. L.C.Crossman@ncl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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