Linked Life Data

15820436

Source:http://linkedlifedata.com/resource/pubmed/id/15820436

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-4-11
pubmed:abstractText
During the treatments of carcinomas of the cervix, anemia is relatively frequent and its origin is complex combining often hemorrhage, iron deprivation, inflammatory reactions and infection. The frequency of the primary anemia (hemoglobin level<12 g/dl) is correlated with clinical stage and varies from one publication to another, mainly from 25% for stage I, to 33% for stage II and can approach 40% for stage III. Anemia is correlated with patient survival and it appears to be one of the most powerful prognostic factor after clinical stage and tumor size. Anemia is a bad prognostic factor related to stage and tumor size but it has not been proven to be an independent factor. Anemia increases hypoxia of cervix carcinomas, which is an independent prognostic factor for patients N0. Moreover, we know that the oxygenation of these tumors is correlated with hemoglobin levels. The normalization of Hb levels by transfusion could certainly modify the prognosis of patients anemic before treatment, or of those becoming anemic during radiotherapy treatment. For smokers, anemia is certainly more important that we can appreciate from the Hb levels only, by the presence of carboxyhemoglobin. Concomitant chemotherapies with cisplatin compounds are actually standards and they can largely increase the risk of inducing anemia, therefore more than 50% of patients will experiment it during their different treatments. Transfusion is recommended by the SOR (Standards Options and Recommendations of the Fédération nationale des centres de lutte contre le cancer) under 10 g/dl. The use of erythropoietin is a therapeutic option for Hb levels between 10 and 12 g/dl and strongly recommended after a Hb normalization by blood transfusion. For 70% of patients who respond to erythropoietin, a better control of the Hb level is obtained. The impact of this anemia on quality of life and treatments compliance justifies the use of erythropoietin, especially in cancers for which treatments induce a deep fatigue and a very bad tolerance, which could be a limiting factor.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1278-3218
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-95
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15820436-Anemia, pubmed-meshheading:15820436-Antineoplastic Agents, pubmed-meshheading:15820436-Blood Transfusion, pubmed-meshheading:15820436-Carboxyhemoglobin, pubmed-meshheading:15820436-Cell Hypoxia, pubmed-meshheading:15820436-Cisplatin, pubmed-meshheading:15820436-Combined Modality Therapy, pubmed-meshheading:15820436-Erythropoietin, pubmed-meshheading:15820436-Female, pubmed-meshheading:15820436-Hemoglobins, pubmed-meshheading:15820436-Humans, pubmed-meshheading:15820436-Incidence, pubmed-meshheading:15820436-Prognosis, pubmed-meshheading:15820436-Quality of Life, pubmed-meshheading:15820436-Radiotherapy, pubmed-meshheading:15820436-Radiotherapy Dosage, pubmed-meshheading:15820436-Randomized Controlled Trials as Topic, pubmed-meshheading:15820436-Retrospective Studies, pubmed-meshheading:15820436-Risk Factors, pubmed-meshheading:15820436-Smoking, pubmed-meshheading:15820436-Uterine Cervical Neoplasms
pubmed:year
2005
pubmed:articleTitle
[Anemia impact on treatments of cervical carcinomas].
pubmed:affiliation
Département de radiothérapie, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandoeuvre-lès-Nancy, France. c.marchal@nancy.fnclcc.fr
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Review