Source:http://linkedlifedata.com/resource/pubmed/id/15817640
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2005-5-30
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pubmed:abstractText |
Recent studies of myoglobin (Mb) knockout (myo-/-) mice have extended our understanding of Mb's diverse functions and have demonstrated a complex array of compensatory mechanisms. The present study was aimed at detailed analysis of cardiac function and exercise endurance in myo-/- mice and at providing evidence for Mb's functional relevance. Myo-/- isolated working hearts display decreased contractility (dP/dtmax 3883+/-351 vs. 4618+/-268 mmHg/sec, myo-/- vs. WT, P<0.005). Due to a shift in sympathetic/parasympathetic tone, heart rate is reduced in conscious myo mice-/- (615+/-33 vs. 645+/-27 bpm, myo-/- vs. WT, P<0.001). Oxygen consumption (VO2) under resting conditions (3082+/-413 vs. 4452+/-552 ml x kg(-1) x h(-1), myo-/- vs. WT, P<0.001) and exercise endurance, as determined by spiroergometry, are decreased (466+/-113 vs. 585+/-153 m, myo-/- vs. WT, P<0.01). Conscious myo-/- mice evaluated by echocardiography display lowered cardiac output (0.64+/-0.06 vs. 0.75+/-0.09 ml x min(-1) x g(-1), myo-/- vs. WT, P<0.001), impaired systolic shortening (60+/-3.5 vs. 65+/-4%, myo-/- vs. WT, P<0.001) and fail to respond to beta1-stimulation. Strikingly, the latter cardiac effects of Mb deficiency can be partially attenuated by NOS inhibition. Loss of Mb results in a distinct phenotype, even under resting conditions, and the importance of oxygen supply and nitric oxide scavenging by Mb is clearly demonstrated at the conscious animal level.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Myoglobin,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1530-6860
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1015-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15817640-Animals,
pubmed-meshheading:15817640-Atropine,
pubmed-meshheading:15817640-Blood Pressure,
pubmed-meshheading:15817640-Cardiac Output,
pubmed-meshheading:15817640-Coronary Circulation,
pubmed-meshheading:15817640-Echocardiography,
pubmed-meshheading:15817640-Free Radical Scavengers,
pubmed-meshheading:15817640-Heart,
pubmed-meshheading:15817640-Heart Rate,
pubmed-meshheading:15817640-Mice,
pubmed-meshheading:15817640-Mice, Knockout,
pubmed-meshheading:15817640-Myoglobin,
pubmed-meshheading:15817640-Nitric Oxide,
pubmed-meshheading:15817640-Nitric Oxide Synthase,
pubmed-meshheading:15817640-Oxygen Consumption,
pubmed-meshheading:15817640-Physical Endurance,
pubmed-meshheading:15817640-Physical Exertion
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pubmed:year |
2005
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pubmed:articleTitle |
Oxygen supply and nitric oxide scavenging by myoglobin contribute to exercise endurance and cardiac function.
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pubmed:affiliation |
Medizinische Klinik I, RWTH Aachen, Aachen, Germany. mmerx@ukaachen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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