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rdf:type |
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lifeskim:mentions |
umls-concept:C0024337,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0039337,
umls-concept:C0042285,
umls-concept:C0086597,
umls-concept:C0205439,
umls-concept:C0237677,
umls-concept:C1519623,
umls-concept:C1537081,
umls-concept:C1564960
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pubmed:dateCreated |
2005-4-25
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pubmed:abstractText |
The sweet taste inhibitor lactisole acts on the human sweet taste receptor heteromer TAS1R2-TAS1R3 but not on its rodent counterpart. Recently, it was shown that the lactisole sensitivity of the human sweet taste receptor involves the part of TAS1R3 encompassing the seven transmembrane regions but not the huge N-terminal domain. Using mutational analysis we investigated which amino acid residues distinguish lactisole insensitive rat from sensitive human T1R3 receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-10052456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-10480680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-11509186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-11894099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-11917125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-12208493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-12379598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-12706725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-12917372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-15153113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-15299024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-15353592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-15668251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-3045756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-3737735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-4204310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-6810399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-7812727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15817126-8976529
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2202
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15817126-Animals,
pubmed-meshheading:15817126-Benzene Derivatives,
pubmed-meshheading:15817126-Binding Sites,
pubmed-meshheading:15817126-Cell Line,
pubmed-meshheading:15817126-Genetic Variation,
pubmed-meshheading:15817126-Humans,
pubmed-meshheading:15817126-Lysine,
pubmed-meshheading:15817126-Rats,
pubmed-meshheading:15817126-Receptors, G-Protein-Coupled,
pubmed-meshheading:15817126-Sweetening Agents,
pubmed-meshheading:15817126-Valine
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pubmed:year |
2005
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pubmed:articleTitle |
Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor.
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pubmed:affiliation |
German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Molecular Genetics, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. winnig@mail.dife.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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