Linked Life Data

15816823

Source:http://linkedlifedata.com/resource/pubmed/id/15816823

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-4-8
pubmed:abstractText
Neurotrophins are important modulators of epithelial-mesenchymal interactions. Previously, we had shown that brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tyrosine kinase B (TrkB) are prominently involved in the control of murine hair follicle cycling. We now show that BDNF and TrkB are also expressed in the human hair follicle in a manner that is both hair cycle dependent and suggestive of epithelial-mesenchymal cross-talk between BDNF-secreting dermal papilla fibroblasts of anagen hair follicles and subpopulations of TrkB+ hair follicle keratinocytes. As functional evidence for an involvement of BDNF/TrkB in human hair growth control, we show in organ-cultured human anagen hair follicles that 50 ng per mL BDNF significantly inhibit hair shaft elongation, induce premature catagen development, and inhibit keratinocyte proliferation. Quantitative real-time rtPCR analysis demonstrates upregulation of the potent catagen inducer, transforming growth factor beta2 (TGFbeta2) by BDNF, whereas catagen induction by BDNF was partially reversible through co-administration of TGFbeta-neutralizing antibody. This suggests that TrkB-mediated signaling promotes the switch between anagen and catagen at least in part via upregulation of TGFbeta2. Thus, human scalp hair follicles are both a source and target of bioregulation by BDNF, which invites to target TrkB-mediated signaling for therapeutic hair growth modulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-85
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15816823-Antibodies, pubmed-meshheading:15816823-Brain-Derived Neurotrophic Factor, pubmed-meshheading:15816823-Cell Division, pubmed-meshheading:15816823-Epithelium, pubmed-meshheading:15816823-Gene Expression Regulation, Developmental, pubmed-meshheading:15816823-Hair Follicle, pubmed-meshheading:15816823-Humans, pubmed-meshheading:15816823-Immunohistochemistry, pubmed-meshheading:15816823-Keratinocytes, pubmed-meshheading:15816823-Mesoderm, pubmed-meshheading:15816823-Organ Culture Techniques, pubmed-meshheading:15816823-RNA, Messenger, pubmed-meshheading:15816823-Receptor, trkB, pubmed-meshheading:15816823-Recombinant Proteins, pubmed-meshheading:15816823-Transcription, Genetic, pubmed-meshheading:15816823-Transforming Growth Factor beta, pubmed-meshheading:15816823-Transforming Growth Factor beta2, pubmed-meshheading:15816823-Up-Regulation
pubmed:year
2005
pubmed:articleTitle
Control of human hair growth by neurotrophins: brain-derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor beta2 expression.
pubmed:affiliation
Department of Internal Medicine, Biomedical Research Center, University Medicine Charité, Campus Virchow Hospital, Berlin, Germany. frl_peters@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't