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rdf:type |
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lifeskim:mentions |
umls-concept:C0020852,
umls-concept:C0020861,
umls-concept:C0040556,
umls-concept:C0205554,
umls-concept:C0239307,
umls-concept:C0348026,
umls-concept:C0680730,
umls-concept:C0683597,
umls-concept:C0918012,
umls-concept:C1096776,
umls-concept:C1148554,
umls-concept:C1510996
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-7
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pubmed:abstractText |
The LIAISON system is a fully automated system based on chemiluminescence and antigen bound to magnetic microparticles. The system allows fast and precise measurement of Toxoplasma-specific immunoglobulin G (IgG) and IgM antibody levels and measurement of the IgG avidity index even at low levels of Toxoplasma-specific IgG antibodies in a single step without manual interference. Seven European centers participated in a multicenter evaluation of the LIAISON system. The sensitivity and specificity of the LIAISON system compared to the Sabin-Feldman dye test were 99.3 and 96.8%, respectively. In a comparison of the LIAISON Toxoplasma-specific IgM assay with an immunosorbent agglutination assay, the LIAISON assay had a sensitivity of 96.7% and a specificity of 95.4%. The LIAISON IgG assay showed agreements of 91, 100, and 100% with the AXSYM IgG (Abbott), VIDAS IgG (bioMerieux), and Platelia IgG (Bio-Rad) assays, respectively. The LIAISON IgM assay showed agreements of 95% with the AXSYM IgM and Platelia IgM assays, 96% with the ISAGA IgM assay (bioMerieux), and 97% with the VIDAS IgM assay. The coefficient of correlation between the LIAISON system and the VIDAS Toxoplasma-specific IgG avidity index was 0.81. By use of the Toxoplasma-specific IgG avidity index assay with specific IgM-positive samples, the diagnosis of infection with Toxoplasma gondii in early pregnancy has been improved significantly. The LIAISON avidity assay is a valuable assay for the exclusion of recently acquired infection with T. gondii (less than 4 months) in pregnant women, and it decreases significantly the necessity for follow-up testing.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-10359407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-10473525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-10602544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-10612889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-10799450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-11174493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-11427427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-11527801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-11561802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-12089270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-12505095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-14662919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-15188723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-1752302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-2229374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-8150014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-8327266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-8440939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-8968902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-9230365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-9488827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-9738042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15814967-9823527
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1570-4
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pubmed:dateRevised |
2010-9-20
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pubmed:meshHeading |
pubmed-meshheading:15814967-Animals,
pubmed-meshheading:15814967-Antibody Affinity,
pubmed-meshheading:15814967-Automation,
pubmed-meshheading:15814967-Europe,
pubmed-meshheading:15814967-Female,
pubmed-meshheading:15814967-Humans,
pubmed-meshheading:15814967-Immunoassay,
pubmed-meshheading:15814967-Immunoglobulin G,
pubmed-meshheading:15814967-Immunoglobulin M,
pubmed-meshheading:15814967-Infant, Newborn,
pubmed-meshheading:15814967-Laboratories,
pubmed-meshheading:15814967-Pregnancy,
pubmed-meshheading:15814967-Pregnancy Complications, Parasitic,
pubmed-meshheading:15814967-Reagent Kits, Diagnostic,
pubmed-meshheading:15814967-Sensitivity and Specificity,
pubmed-meshheading:15814967-Toxoplasma,
pubmed-meshheading:15814967-Toxoplasmosis,
pubmed-meshheading:15814967-Toxoplasmosis, Congenital
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pubmed:year |
2005
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pubmed:articleTitle |
European multicenter study of the LIAISON automated diagnostic system for determination of Toxoplasma gondii-specific immunoglobulin G (IgG) and IgM and the IgG avidity index.
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pubmed:affiliation |
WHO/FAO International Centre for Research and Reference on Toxoplasmosis, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. eskildp@dadlnet.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Evaluation Studies
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