| pubmed-article:15814666 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15814666 | lifeskim:mentions | umls-concept:C0253023 | lld:lifeskim |
| pubmed-article:15814666 | lifeskim:mentions | umls-concept:C0596402 | lld:lifeskim |
| pubmed-article:15814666 | lifeskim:mentions | umls-concept:C1511625 | lld:lifeskim |
| pubmed-article:15814666 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:15814666 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:15814666 | lifeskim:mentions | umls-concept:C1539478 | lld:lifeskim |
| pubmed-article:15814666 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:15814666 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15814666 | pubmed:dateCreated | 2005-4-7 | lld:pubmed |
| pubmed-article:15814666 | pubmed:abstractText | The cytotoxic function of CD178 (Fas ligand (FasL)) is critical to the maintenance of peripheral tolerance and immune-mediated tissue pathology. The active site of FasL resides at the FasL extracellular region (FasL(Ext)) and it functions through binding/cross-linking Fas receptor on target cells. In this study, we report that FasL(Ext)-mediated cytotoxicity is regulated by the FasL cytoplasmic tail (FasL(Cyt)). Deleting the N-terminal 2-70 aa (delta70) or N-terminal 2-33 aa (delta33) reduced the cytotoxic strength as much as 30- to 100-fold. By contrast, change in the cytotoxic strength was not observed with FasL deleted of the proline-rich domains (45-74 aa, delta PRD) in the FasL(Cyt). Our study identifies a novel function of FasL(Cyt) and demonstrates that FasL(2-33), a sequence unique to FasL, is critically required for the optimal expression of FasL(Ext)-mediated cytotoxicity. | lld:pubmed |
| pubmed-article:15814666 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15814666 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15814666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15814666 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15814666 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15814666 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15814666 | pubmed:author | pubmed-author:KoikeTakaoT | lld:pubmed |
| pubmed-article:15814666 | pubmed:author | pubmed-author:XiaoShengS | lld:pubmed |
| pubmed-article:15814666 | pubmed:author | pubmed-author:JodoSatoshiS | lld:pubmed |
| pubmed-article:15814666 | pubmed:author | pubmed-author:JuShyr-TeST | lld:pubmed |
| pubmed-article:15814666 | pubmed:author | pubmed-author:PidiyarVyanka... | lld:pubmed |
| pubmed-article:15814666 | pubmed:author | pubmed-author:SharmaRahulR | lld:pubmed |
| pubmed-article:15814666 | pubmed:author | pubmed-author:FurusakiAkira... | lld:pubmed |
| pubmed-article:15814666 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15814666 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15814666 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15814666 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15814666 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15814666 | pubmed:pagination | 4470-4 | lld:pubmed |
| pubmed-article:15814666 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
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| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
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| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:meshHeading | pubmed-meshheading:15814666... | lld:pubmed |
| pubmed-article:15814666 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15814666 | pubmed:articleTitle | Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand-mediated cytotoxicity. | lld:pubmed |
| pubmed-article:15814666 | pubmed:affiliation | Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan. | lld:pubmed |
| pubmed-article:15814666 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15814666 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15814666 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:356 | entrezgene:pubmed | pubmed-article:15814666 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15814666 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15814666 | lld:pubmed |
