Linked Life Data

15814434

Source:http://linkedlifedata.com/resource/pubmed/id/15814434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-4-7
pubmed:abstractText
Platelets play an important role in coagulation, in maintenance of hemostasis, and in the pathophysiology of thrombotic diseases. In response to blood vessel injury, platelets accumulate at the site, recruit other platelets, promote clotting, and form a hemostatic plug to prevent hemorrhage. By contrast, several inhibitory mechanisms modulate platelet function and act in a synergistic manner to prevent pathologic thrombus formation. This review focuses on the principal endogenous inhibitors of platelet function and the central role of the normal endothelium in these inhibitory processes. The main endothelium-derived platelet inhibitors include nitric oxide, prostacyclin, and Ecto-ADPase/CD39/NTPDase. Each of these factors is discussed in turn, and the specific mechanisms by which they inhibit platelet function are reviewed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1073-9688
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-58
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Endogenous mechanisms of inhibition of platelet function.
pubmed:affiliation
Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, N.I.H., Extramural