|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-4-7
|
|
pubmed:abstractText |
There are only a few reports of thrombocytopenia associated with clinical doses of teicoplanin, a glycopeptide antibiotic used against Gram-positive bacteria. We investigated 39 patients receiving teicoplanin; 31 were thrombocytopenic with platelet counts between 1-105 x 10(9)/l and 8 were not thrombocytopenic. We identified 14 thrombocytopenic cases (45%) and two (25%) non-thrombocytopenic cases with IgG teicoplanin-dependent platelet-reactive antibodies. Use of glycoprotein (GP) capture enzyme-linked immunosorbent assay with platelets and GPIIb/IIIa transfected Chinese Hamster Ovary cells as well as flow cytometry with GP-deficient platelets indicated that the GPIIb/IIIa complex is a major target antigen of these antibodies.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0007-1048
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
129
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
279-81
|
|
pubmed:dateRevised |
2005-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:15813857-Animals,
pubmed-meshheading:15813857-Anti-Bacterial Agents,
pubmed-meshheading:15813857-Antibodies,
pubmed-meshheading:15813857-Antigen-Antibody Reactions,
pubmed-meshheading:15813857-Blood Platelets,
pubmed-meshheading:15813857-CHO Cells,
pubmed-meshheading:15813857-Cricetinae,
pubmed-meshheading:15813857-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15813857-Flow Cytometry,
pubmed-meshheading:15813857-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:15813857-Humans,
pubmed-meshheading:15813857-Immunoglobulin G,
pubmed-meshheading:15813857-Platelet Glycoprotein GPIIb-IIIa Complex,
pubmed-meshheading:15813857-Teicoplanin,
pubmed-meshheading:15813857-Thrombocytopenia
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Teicoplanin-dependent antibodies: detection and characterization.
|
|
pubmed:affiliation |
National Blood Service, Cambridge, UK. sfg21@cam.ac.uk
|
|
pubmed:publicationType |
Journal Article
|
