| pubmed-article:15810887 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15810887 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:15810887 | lifeskim:mentions | umls-concept:C0009337 | lld:lifeskim |
| pubmed-article:15810887 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:15810887 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:15810887 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15810887 | lifeskim:mentions | umls-concept:C1333079 | lld:lifeskim |
| pubmed-article:15810887 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:15810887 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15810887 | pubmed:dateCreated | 2005-4-6 | lld:pubmed |
| pubmed-article:15810887 | pubmed:abstractText | Previous studies have shown that pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta up-regulate type VII collagen gene (COL7A1) expression in cultured dermal fibroblasts. The present study was designed to investigate the effects of TNF-alpha and IL-1beta on COL7A1 expression in epidermal keratinocytes. We demonstrated that both TNF-alpha and IL-1beta reduced COL7A1 expression in epidermal keratinocytes in an additive manner, whereas they increased COL7A1 expression in dermal fibroblasts. Thus, regulation of COL7A1 by pro-inflammatory cytokines is cell type specific. In particular, the inhibitory effects of TNF-alpha and IL-1beta occurred, at least in part, at the transcriptional level. Finally, we demonstrated that TNF-alpha and IL-1beta enhanced the TGF-beta-mediated up-regulation of COL7A1 expression in HaCaT keratinocytes, suggesting that the combination of TGF-beta and TNF-alpha or IL-1beta induces a signaling pathway that is completely different from that induced by either pro-inflammatory cytokine alone. | lld:pubmed |
| pubmed-article:15810887 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15810887 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15810887 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15810887 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15810887 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15810887 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15810887 | pubmed:issn | 0906-6705 | lld:pubmed |
| pubmed-article:15810887 | pubmed:author | pubmed-author:TakagakiKeiic... | lld:pubmed |
| pubmed-article:15810887 | pubmed:author | pubmed-author:HanadaKatsumi... | lld:pubmed |
| pubmed-article:15810887 | pubmed:author | pubmed-author:SawamuraDaisu... | lld:pubmed |
| pubmed-article:15810887 | pubmed:author | pubmed-author:HashimotoIsao... | lld:pubmed |
| pubmed-article:15810887 | pubmed:author | pubmed-author:KonAtsushiA | lld:pubmed |
| pubmed-article:15810887 | pubmed:author | pubmed-author:TakedaHitoshi... | lld:pubmed |
| pubmed-article:15810887 | pubmed:author | pubmed-author:ItoNorikoN | lld:pubmed |
| pubmed-article:15810887 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15810887 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:15810887 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15810887 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15810887 | pubmed:pagination | 289-94 | lld:pubmed |
| pubmed-article:15810887 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15810887 | pubmed:meshHeading | pubmed-meshheading:15810887... | lld:pubmed |
| pubmed-article:15810887 | pubmed:meshHeading | pubmed-meshheading:15810887... | lld:pubmed |
| pubmed-article:15810887 | pubmed:meshHeading | pubmed-meshheading:15810887... | lld:pubmed |
| pubmed-article:15810887 | pubmed:meshHeading | pubmed-meshheading:15810887... | lld:pubmed |
| pubmed-article:15810887 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15810887 | pubmed:articleTitle | Keratinocyte-specific modulation of type VII collagen gene expression by pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta). | lld:pubmed |
| pubmed-article:15810887 | pubmed:affiliation | Department of Dermatology, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan. | lld:pubmed |
| pubmed-article:15810887 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15810887 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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