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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-6
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pubmed:abstractText |
CD1d-restricted T-cells are activated by glycolipids presented by the major histocompatibility complex class-Ib molecule CD1d, found on the surface of antigen-presenting cells (APC). This interaction between APC, most notably dendritic cells (DC), and CD1d-restricted T-cells is an important regulatory step in the initiation of adaptive immune responses. It is well known that DC play a crucial role in the induction of contact hypersensitivity (CHS), a frequently studied form of in vivo T-cell-mediated immunity. In this study, we show that CD1d-restricted T-cells are also necessary for CHS, because both wild-type mice treated systemically or topically with CD1d glycolipid antagonists and CD1d-restricted T-cell-null mice have markedly diminished CHS responses. Thus, pharmacologic antagonists of CD1d can be used as effective inhibitors of CHS, a prototype for a variety of delayed-type tissue hypersensitivity responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1d,
http://linkedlifedata.com/resource/pubmed/chemical/DPPE-PEG2000,
http://linkedlifedata.com/resource/pubmed/chemical/Glycolipids,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazolone,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0906-6705
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
250-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15810882-Administration, Topical,
pubmed-meshheading:15810882-Animals,
pubmed-meshheading:15810882-Antigen Presentation,
pubmed-meshheading:15810882-Antigens, CD1,
pubmed-meshheading:15810882-Antigens, CD1d,
pubmed-meshheading:15810882-Cell Line,
pubmed-meshheading:15810882-Dendritic Cells,
pubmed-meshheading:15810882-Dermatitis,
pubmed-meshheading:15810882-Dermatitis, Contact,
pubmed-meshheading:15810882-Dose-Response Relationship, Drug,
pubmed-meshheading:15810882-Glycolipids,
pubmed-meshheading:15810882-Hypersensitivity,
pubmed-meshheading:15810882-Killer Cells, Natural,
pubmed-meshheading:15810882-Major Histocompatibility Complex,
pubmed-meshheading:15810882-Mice,
pubmed-meshheading:15810882-Mice, Inbred BALB C,
pubmed-meshheading:15810882-Mice, Inbred C57BL,
pubmed-meshheading:15810882-Mice, Transgenic,
pubmed-meshheading:15810882-Mutation,
pubmed-meshheading:15810882-Oxazolone,
pubmed-meshheading:15810882-Phosphatidylethanolamines,
pubmed-meshheading:15810882-Polyethylene Glycols,
pubmed-meshheading:15810882-Receptors, Antigen, T-Cell
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pubmed:year |
2005
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pubmed:articleTitle |
CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity.
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pubmed:affiliation |
Gastrointestinal Division, Brigham and Women's Hospital, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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