Linked Life Data

15809971

Source:http://linkedlifedata.com/resource/pubmed/id/15809971

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-4-11
pubmed:abstractText
Initiation of intestinal tumours occurs as a consequence of aberrant Wnt signalling. This causes altered expression of a number of genes which provides the mechanistic basis of neoplastic change in normal epithelium. In order to identify these genes, expression profiles of normal intestinal mucosa and intestinal adenomas from multiple intestinal neoplasia (Min) mice were compared. A total of 116 genes were found to show significant changes in expression in adenomas compared with normal mucosa. Functional classification of these genes clearly identified the biological processes of cellular adhesion and matrix remodelling to be profoundly affected. Notably, three members of the matrix metalloproteinase (Mmp) gene family (Mmp10, Mmp13, and Mmp14) were consistently up-regulated in tumour tissue. To extend these data, expression of 17 Mmp genes was defined using quantitative reverse transcriptase-polymerase chain reaction (Q-RT-PCR). Several Mmp genes were profoundly up-regulated and every tumour showed overexpression of at least four Mmp genes. These results underscore the probable importance of interactions between the intestinal epithelium and stroma in early tumour development. Furthermore, the inferred role of Mmps at the adenomatous stage of tumourigenesis suggests that this may represent the optimal therapeutic window for the use of Mmp antagonists as anti-cancer agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3417
pubmed:author
pubmed:copyrightInfo
2005 Pathological Society of Great Britain and Ireland
pubmed:issnType
Print
pubmed:volume
206
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
100-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15809971-Adenoma, pubmed-meshheading:15809971-Animals, pubmed-meshheading:15809971-Collagenases, pubmed-meshheading:15809971-Gene Expression, pubmed-meshheading:15809971-Gene Expression Profiling, pubmed-meshheading:15809971-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15809971-Intestinal Mucosa, pubmed-meshheading:15809971-Intestinal Neoplasms, pubmed-meshheading:15809971-Matrix Metalloproteinase 10, pubmed-meshheading:15809971-Matrix Metalloproteinase 13, pubmed-meshheading:15809971-Matrix Metalloproteinase 14, pubmed-meshheading:15809971-Matrix Metalloproteinases, pubmed-meshheading:15809971-Matrix Metalloproteinases, Membrane-Associated, pubmed-meshheading:15809971-Metalloendopeptidases, pubmed-meshheading:15809971-Mice, pubmed-meshheading:15809971-Mice, Mutant Strains, pubmed-meshheading:15809971-Neoplasm Staging, pubmed-meshheading:15809971-Neoplasms, Multiple Primary, pubmed-meshheading:15809971-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:15809971-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2005
pubmed:articleTitle
Expression profiling of murine intestinal adenomas reveals early deregulation of multiple matrix metalloproteinase (Mmp) genes.
pubmed:affiliation
Oxford Molecular Pathology Group, The Women's Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't