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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2005-4-12
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pubmed:abstractText |
We have previously linked hereditary progressive cardiac conduction defect (hereditary Lenègre's disease) to a loss-of-function mutation in the gene encoding the main cardiac Na+ channel, SCN5A. In the present study, we investigated heterozygous Scn5a-knockout mice (Scn5a+/- mice) as a model for hereditary Lenègre's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:CharpentierFlavienF,
pubmed-author:ColledgeWilliam HWH,
pubmed-author:DemolombeSophieS,
pubmed-author:EscandeDenisD,
pubmed-author:EscoubetBrigitteB,
pubmed-author:GoddardCatharine ACA,
pubmed-author:GraceAndrew AAA,
pubmed-author:Griol-CharhbiliViolaineV,
pubmed-author:GrosDanielD,
pubmed-author:Jarry-GuichardThérèseT,
pubmed-author:LéoniAnne-LaureAL,
pubmed-author:Le BouterSabrinaS,
pubmed-author:MarionneauCélineC,
pubmed-author:RicherChristineC,
pubmed-author:RoyerAnneA,
pubmed-author:SteenmanMarjaM,
pubmed-author:de BakkerJacques M TJM,
pubmed-author:van RijenHarold V MHV,
pubmed-author:van VeenToon A BTA
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1738-46
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:15809371-Age Factors,
pubmed-meshheading:15809371-Animals,
pubmed-meshheading:15809371-Cardiomegaly,
pubmed-meshheading:15809371-Connexins,
pubmed-meshheading:15809371-Disease Models, Animal,
pubmed-meshheading:15809371-Electrocardiography,
pubmed-meshheading:15809371-Fibrosis,
pubmed-meshheading:15809371-Gene Expression Regulation,
pubmed-meshheading:15809371-Genetic Diseases, Inborn,
pubmed-meshheading:15809371-Heart Block,
pubmed-meshheading:15809371-Heart Conduction System,
pubmed-meshheading:15809371-Heart Ventricles,
pubmed-meshheading:15809371-Heterozygote,
pubmed-meshheading:15809371-Mice,
pubmed-meshheading:15809371-Mice, Knockout,
pubmed-meshheading:15809371-Sodium Channels,
pubmed-meshheading:15809371-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis.
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pubmed:affiliation |
INSERM U533, Institut du Thorax, Faculté de Médecine, Nantes, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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