| pubmed-article:15808664 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15808664 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15808664 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:15808664 | lifeskim:mentions | umls-concept:C0903042 | lld:lifeskim |
| pubmed-article:15808664 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15808664 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:15808664 | lifeskim:mentions | umls-concept:C0475224 | lld:lifeskim |
| pubmed-article:15808664 | lifeskim:mentions | umls-concept:C1419064 | lld:lifeskim |
| pubmed-article:15808664 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15808664 | pubmed:dateCreated | 2005-4-5 | lld:pubmed |
| pubmed-article:15808664 | pubmed:abstractText | Prostaglandin E(2) (PGE(2)) mediates a variety of both innate and adaptive immunity responses through 4 distinct receptors, EP1-4. Recent studies have suggested the physiological and pathological role of EP4 in various inflammatory diseases. In this study, we investigated the importance of the EP4 receptor, and the efficacy of a selective EP4 agonist to alter hepatic ischemia/reperfusion (I/R) injury, an important cause of damage in liver resection and transplantation. We used an established murine I/R injury model, 70% partial hepatic ischemia for 90 minutes in male C57BL/6 mice. The local expression of EP4 messenger RNA (mRNA) in the naive and the ischemic liver at 2 hours after reperfusion was examined using RT-PCR analysis. Some mice received the EP4 selective agonist during I/R. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured as markers of hepatic injury. EP4 expression in the liver was significantly up-regulated at 2 hours after reperfusion. Furthermore, treatment with EP4 agonist significantly inhibited hepatic injury at 6 hours after reperfusion. Our data suggest an inhibitory role of EP4 PGE(2) receptor in hepatic I/R injury and the therapeutic efficacy of a selective EP4 agonist for liver protection. | lld:pubmed |
| pubmed-article:15808664 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15808664 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15808664 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15808664 | pubmed:issn | 0041-1345 | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:IkedaNN | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:NakajimaYY | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:MizunoTT | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:HamadaKK | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:AkashiSS | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:NollHH | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:KuzumotoYY | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:KanehiroHH | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:SheGG | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:TsuruiYY | lld:pubmed |
| pubmed-article:15808664 | pubmed:author | pubmed-author:KashizukaHH | lld:pubmed |
| pubmed-article:15808664 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15808664 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:15808664 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15808664 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15808664 | pubmed:pagination | 422-4 | lld:pubmed |
| pubmed-article:15808664 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15808664 | pubmed:meshHeading | pubmed-meshheading:15808664... | lld:pubmed |
| pubmed-article:15808664 | pubmed:articleTitle | Role of EP4 prostaglandin E2 receptor in the ischemic liver. | lld:pubmed |
| pubmed-article:15808664 | pubmed:affiliation | Department of Surgery, Nara Medical University School of Medicine, Nara, Japan. | lld:pubmed |
| pubmed-article:15808664 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:19219 | entrezgene:pubmed | pubmed-article:15808664 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:15808664 | lld:entrezgene |
