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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-4-5
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pubmed:abstractText |
Prostaglandin E(2) (PGE(2)) mediates a variety of both innate and adaptive immunity responses through 4 distinct receptors, EP1-4. Recent studies have suggested the physiological and pathological role of EP4 in various inflammatory diseases. In this study, we investigated the importance of the EP4 receptor, and the efficacy of a selective EP4 agonist to alter hepatic ischemia/reperfusion (I/R) injury, an important cause of damage in liver resection and transplantation. We used an established murine I/R injury model, 70% partial hepatic ischemia for 90 minutes in male C57BL/6 mice. The local expression of EP4 messenger RNA (mRNA) in the naive and the ischemic liver at 2 hours after reperfusion was examined using RT-PCR analysis. Some mice received the EP4 selective agonist during I/R. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured as markers of hepatic injury. EP4 expression in the liver was significantly up-regulated at 2 hours after reperfusion. Furthermore, treatment with EP4 agonist significantly inhibited hepatic injury at 6 hours after reperfusion. Our data suggest an inhibitory role of EP4 PGE(2) receptor in hepatic I/R injury and the therapeutic efficacy of a selective EP4 agonist for liver protection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP4...
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pubmed:status |
MEDLINE
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pubmed:issn |
0041-1345
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pubmed:author |
pubmed-author:AkashiSS,
pubmed-author:HamadaKK,
pubmed-author:IkedaNN,
pubmed-author:KanehiroHH,
pubmed-author:KashizukaHH,
pubmed-author:KuzumotoYY,
pubmed-author:MizunoTT,
pubmed-author:NakajimaYY,
pubmed-author:NollHH,
pubmed-author:SheGG,
pubmed-author:TsuruiYY
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
422-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15808664-Alanine Transaminase,
pubmed-meshheading:15808664-Animals,
pubmed-meshheading:15808664-Aspartate Aminotransferases,
pubmed-meshheading:15808664-Base Sequence,
pubmed-meshheading:15808664-DNA Primers,
pubmed-meshheading:15808664-Dinoprostone,
pubmed-meshheading:15808664-Inflammation,
pubmed-meshheading:15808664-Ischemia,
pubmed-meshheading:15808664-Liver Circulation,
pubmed-meshheading:15808664-Male,
pubmed-meshheading:15808664-Mice,
pubmed-meshheading:15808664-Mice, Inbred C57BL,
pubmed-meshheading:15808664-RNA, Messenger,
pubmed-meshheading:15808664-Receptors, Prostaglandin E,
pubmed-meshheading:15808664-Receptors, Prostaglandin E, EP4 Subtype,
pubmed-meshheading:15808664-Reperfusion Injury,
pubmed-meshheading:15808664-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:articleTitle |
Role of EP4 prostaglandin E2 receptor in the ischemic liver.
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pubmed:affiliation |
Department of Surgery, Nara Medical University School of Medicine, Nara, Japan.
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pubmed:publicationType |
Journal Article
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