15808338

Source:http://linkedlifedata.com/resource/pubmed/id/15808338

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017296, umls-concept:C0019932, umls-concept:C0027882, umls-concept:C0038435, umls-concept:C1824952
pubmed:issue	4
pubmed:dateCreated	2005-4-5
pubmed:abstractText	Glucocorticoids are adrenal steroid 'stress' hormones that are important in normal brain function. However, during conditions of excitotoxic injury to neurons, glucocorticoids can exacerbate cell death. A recent study has developed a 'trifecta' of ingenious viral vector-based approaches to modify the neuronal stress response and to diminish this exacerbation both in vitro and in vivo. Stress hormone gene therapy in the brain is now off and running.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7906158
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0165-6147
pubmed:author	pubmed-author:AkamaKeith TKT, pubmed-author:McEwenBruce SBS
pubmed:issnType	Print
pubmed:volume	26
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	169-72
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:15808338-Animals, pubmed-meshheading:15808338-Brain Diseases, pubmed-meshheading:15808338-Gene Expression Regulation, pubmed-meshheading:15808338-Gene Therapy, pubmed-meshheading:15808338-Glucocorticoids, pubmed-meshheading:15808338-Humans, pubmed-meshheading:15808338-Neurons, pubmed-meshheading:15808338-Stress, Physiological
pubmed:year	2005
pubmed:articleTitle	Gene therapy to bet on: protecting neurons from stress hormones.
pubmed:affiliation	The Rockefeller University, Department of Neuroendocrinology, 1230 York Avenue, Box 165, New York, NY 10021-6399, USA.
pubmed:publicationType	Journal Article, Review