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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-4-5
pubmed:abstractText
Hypopituitary patients have an increased risk of vascular mortality that may relate to growth hormone deficiency (GHD). We investigated the effects of 6 months of GH therapy on large- and small-artery function and high-sensitivity C-reactive protein (hsCRP) in a cohort of GH-deficient patients. Sixteen hypopituitary patients were randomized to 6 months of GH therapy or no treatment, then vice versa. hsCRP, 24-h blood pressure (BP) and pulse wave velocity (PWV) were measured and resistance arteries were used to construct concentration-response curves to endothelium-dependent and -independent agents. GH therapy increased IGF-1 from 60 +/- 7.2 to 167 +/- 16.2 microg/l [confidence interval (CI) 94.9, 138.8, P < 0.001]. hsCRP declined after 6 months of GH from 3.8 +/- 0.88 to 2.0 +/- 0.49 mg/l (CI 0.73, 3.57, P = 0.006). Mean arterial BP fell from 91.7 +/- 1.5 to 89.3 +/- 1.2 mmHg (CI 0.81, 4.07, P = 0.005), as did PWV (8.1 +/- 0.4 to 6.7 +/- 0.5 m/s). The decline in PWV correlated with the decline in hsCRP (r = 0.68, P = 0.01). Resistance artery function was unchanged after GH therapy. GH replacement may lead to differentially altered production of vasorelaxant agents from the endothelium of large and small arteries. Reduction in vascular inflammation may be associated with reduced vascular risk.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0300-0664
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
473-9
pubmed:dateRevised
2005-8-12
pubmed:meshHeading
pubmed-meshheading:15807879-Adult, pubmed-meshheading:15807879-Aged, pubmed-meshheading:15807879-Arteries, pubmed-meshheading:15807879-Blood Flow Velocity, pubmed-meshheading:15807879-Blood Pressure, pubmed-meshheading:15807879-C-Reactive Protein, pubmed-meshheading:15807879-Dose-Response Relationship, Drug, pubmed-meshheading:15807879-Endothelium, Vascular, pubmed-meshheading:15807879-Female, pubmed-meshheading:15807879-Growth Hormone, pubmed-meshheading:15807879-Hormone Replacement Therapy, pubmed-meshheading:15807879-Humans, pubmed-meshheading:15807879-Hypopituitarism, pubmed-meshheading:15807879-Insulin-Like Growth Factor I, pubmed-meshheading:15807879-Male, pubmed-meshheading:15807879-Middle Aged, pubmed-meshheading:15807879-Myography, pubmed-meshheading:15807879-Pulse, pubmed-meshheading:15807879-Vasodilator Agents
pubmed:year
2005
pubmed:articleTitle
Growth hormone replacement reduces C-reactive protein and large-artery stiffness but does not alter endothelial function in patients with adult growth hormone deficiency.
pubmed:affiliation
Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial