Source:http://linkedlifedata.com/resource/pubmed/id/15806369
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0007113,
umls-concept:C0024485,
umls-concept:C0030705,
umls-concept:C0032743,
umls-concept:C0205179,
umls-concept:C0600558,
umls-concept:C0681842,
umls-concept:C0814225,
umls-concept:C0871261,
umls-concept:C1517324,
umls-concept:C1517927,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707455,
umls-concept:C2911692
|
| pubmed:issue |
8
|
| pubmed:dateCreated |
2005-7-21
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| pubmed:abstractText |
The aim of this study was to compare CT, MRI and FDG-PET in the prediction of outcome of neoadjuvant radiochemotherapy in patients with locally advanced primary rectal cancer. A total of 23 patients with T3/4 rectal cancer underwent a preoperative radiochemotherapy combined with regional hyperthermia. Staging was performed using four-slice CT (n=23), 1.5-T MRI (n=10), and (18)F-FDG-PET (n=23) before and 2-4 weeks after completion of neoadjuvant treatment. Response criteria were a change in T category and tumour volume for CT and MRI and a change in glucose uptake (standard uptake value) within the tumour for FDG-PET. Imaging results were compared with those of pretherapy endorectal ultrasound and histopathological findings. Histopathology showed a response to neoadjuvant therapy in 13 patients whereas 10 patients were classified as nonresponders. The mean SUV reduction in responders (60+/-14%) was significantly higher than in nonresponders (37+/-31%; P=0.030). The sensitivity and specificity of FDG-PET in identifying response was 100% (CT 54%, MRI 71%) and 60% (CT 80%, MRT 67%). Positive and negative predictive values were 77% (CT 78%, MRI 83%) and 100% (CT 57%, MRI 50%) (PET P=0.002, CT P=0.197, MRI P=0.500). These results suggest that FDG-PET is superior to CT and MRI in predicting response to preoperative multimodal treatment of locally advanced primary rectal cancer.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0938-7994
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1658-66
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15806369-Adenocarcinoma,
pubmed-meshheading:15806369-Female,
pubmed-meshheading:15806369-Fluorodeoxyglucose F18,
pubmed-meshheading:15806369-Humans,
pubmed-meshheading:15806369-Magnetic Resonance Imaging,
pubmed-meshheading:15806369-Male,
pubmed-meshheading:15806369-Middle Aged,
pubmed-meshheading:15806369-Neoadjuvant Therapy,
pubmed-meshheading:15806369-Neoplasm Staging,
pubmed-meshheading:15806369-Positron-Emission Tomography,
pubmed-meshheading:15806369-Predictive Value of Tests,
pubmed-meshheading:15806369-Preoperative Care,
pubmed-meshheading:15806369-Prospective Studies,
pubmed-meshheading:15806369-Radiopharmaceuticals,
pubmed-meshheading:15806369-Rectal Neoplasms,
pubmed-meshheading:15806369-Rectum,
pubmed-meshheading:15806369-Sensitivity and Specificity,
pubmed-meshheading:15806369-Tomography, X-Ray Computed
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: is there a benefit in using functional imaging?
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| pubmed:affiliation |
Klinik für Strahlenheilkunde und PET-Zentrum Berlin Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany. timm.denecke@charite.de
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase III
|