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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-4
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pubmed:abstractText |
Many effects of environmental toxic agents contribute to the deregulation of immune system homeostasis. Here we demonstrate that the effect of airborne suspended matter (ASM) on the generation of mouse T cells is reversible. This reversal can be achieved by an active process that returns the T cells to homeostasis and does not result from the simple effect of ASM deprivation. An accelerated development of thymocytes and increased influx of T-cell progenitors to the thymus in mice exposed to environmental xenobiotics has been postulated. This hypothesis has been confirmed by parallel increases in the percentages of single-positive and triple-negative thymocytes. Enhanced expression of thymocyte surface markers related to positive selection has also been observed. The pathway of T-cell progenitor development is favoured in the bone marrow of mice exposed to ASM.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-10712944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-10799342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-10837053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-10843732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-10852846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11090941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11164617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11181107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11342609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11447288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11535628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11574281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11739504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11778948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-11880642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-12033737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-12375743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-12675203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-14643423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-14697739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-7576564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-8095166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-8207255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-8725948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-9018974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-9124870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-9212330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-9388773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-9393859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-9482912,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15804284-9607924
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
476-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15804284-Air Pollutants,
pubmed-meshheading:15804284-Animals,
pubmed-meshheading:15804284-Apoptosis,
pubmed-meshheading:15804284-Cell Differentiation,
pubmed-meshheading:15804284-Female,
pubmed-meshheading:15804284-Homeostasis,
pubmed-meshheading:15804284-Lymphocyte Count,
pubmed-meshheading:15804284-Membrane Potentials,
pubmed-meshheading:15804284-Mice,
pubmed-meshheading:15804284-Mice, Inbred BALB C,
pubmed-meshheading:15804284-Mitochondria,
pubmed-meshheading:15804284-T-Lymphocyte Subsets,
pubmed-meshheading:15804284-Thymus Gland,
pubmed-meshheading:15804284-Xenobiotics
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pubmed:year |
2005
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pubmed:articleTitle |
T-cell homeostasis in mice exposed to airborne xenobiotics.
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pubmed:affiliation |
Institute of Zoology, Department of Immunology, Warsaw University, Poland. ndrela@biol.uw.edu.pl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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